Phenotypes associated with this allele

• Allele Symbol: Nkx2-1^tm2Rdl
• Allele Name: targeted mutation 2, Roberto Di Lauro
• Allele ID: MGI:4941951
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx2-1^tm2Rdl/Nkx2-1^tm2Rdl	B6.129-Nkx2-1^tm2Rdl	MGI:4941960

Genotype
MGI:4941960

hm1

• Allelic Composition: Nkx2-1^tm2Rdl/Nkx2-1^tm2Rdl
• Genetic Background: B6.129-Nkx2-1^tm2Rdl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:169693 )

• presumably from respiratory failure

endocrine/exocrine glands

abnormal pituitary gland development ( J:169693 )

• pituitary gland development is severely impaired

abnormal Rathke's pouch development ( J:169693 )

• small rudimentary

absent infundibular recess of third ventricle ( J:169693 )

• mice lack the infundibular recess compared with wild-type mice

absent pituitary gland ( J:169693 )

• at E16.5

abnormal thyroid gland development ( J:169693 )

• at E11.5, only a thyroid bud is observed unlike in wild-type mice

absent thyroid gland ( J:169693 )

• at E16.5

nervous system

abnormal pituitary gland development ( J:169693 )

• pituitary gland development is severely impaired

abnormal Rathke's pouch development ( J:169693 )

• small rudimentary

absent infundibular recess of third ventricle ( J:169693 )

• mice lack the infundibular recess compared with wild-type mice

absent pituitary gland ( J:169693 )

• at E16.5

respiratory system

abnormal lung morphology ( J:169693 )

respiratory failure ( J:169693 )