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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Selenoktm1.2Itl
targeted mutation 1.2, inGenious Targeting Laboratory
MGI:4941878
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Selenoktm1.2Itl/Selenoktm1.2Itl involves: BALB/cJ * C57BL/6 MGI:4941882


Genotype
MGI:4941882
hm1
Allelic
Composition		 Selenoktm1.2Itl/Selenoktm1.2Itl
Genetic
Background		 involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selenoktm1.2Itl mutation (0 available); any Selenok mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:169169 )
• West Nile virus (WNV)-infected mice exhibit increased lethality compared with similarly treated wild-type mice

immune system
abnormal neutrophil physiology ( J:169169 )
• neutrophils exhibit decreased receptor-mediated calcium flux compared with wild-type cells
impaired neutrophil chemotaxis ( J:169169 )
• in response to KC treatment and in a model of peritonitis
abnormal T cell physiology ( J:169169 )
• T cells exhibit decreased receptor-mediated calcium flux compared with wild-type cells
• SDF-1 and RANTES-treated T cells exhibit decreased migration compared with wild-type cells
abnormal macrophage physiology ( J:169169 )
• macrophages exhibit decreased receptor-mediated calcium flux compared with wild-type cells
• macrophages exhibit reduced Fcgamma receptor-mediated oxidative bursts compared with wild-type cells
abnormal circulating chemokine level ( J:169169 )
• mice exhibit decreased serum levels of KC and MCP1 compared with wild-type mice
decreased interleukin-6 secretion ( J:169169 )
• from bone marrow-derived macrophage treated with LPS and pIpC
decreased tumor necrosis factor secretion ( J:169169 )
• from bone marrow-derived macrophage treated with LPS and pIpC
increased susceptibility to Flaviviridae infection ( J:169169 )
• West Nile virus (WNV)-infected mice exhibit increased lethality, increased neuronal degeneration, inadequate viral clearance, decreased serum MCP1 and IL6 levels, and increased brain MCP1 level compared with similarly treated wild-type mice
increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:169169 )
• West Nile virus (WNV)-infected mice exhibit increased lethality compared with similarly treated wild-type mice

homeostasis/metabolism
abnormal circulating chemokine level ( J:169169 )
• mice exhibit decreased serum levels of KC and MCP1 compared with wild-type mice

hematopoietic system
abnormal neutrophil physiology ( J:169169 )
• neutrophils exhibit decreased receptor-mediated calcium flux compared with wild-type cells
impaired neutrophil chemotaxis ( J:169169 )
• in response to KC treatment and in a model of peritonitis
abnormal T cell physiology ( J:169169 )
• T cells exhibit decreased receptor-mediated calcium flux compared with wild-type cells
• SDF-1 and RANTES-treated T cells exhibit decreased migration compared with wild-type cells
abnormal macrophage physiology ( J:169169 )
• macrophages exhibit decreased receptor-mediated calcium flux compared with wild-type cells
• macrophages exhibit reduced Fcgamma receptor-mediated oxidative bursts compared with wild-type cells

cellular
impaired neutrophil chemotaxis ( J:169169 )
• in response to KC treatment and in a model of peritonitis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory