Phenotypes associated with this allele

• Allele Symbol: Frrs1l^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4941526
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Frrs1l^tm1a(EUCOMM)Hmgu/Frrs1l^+	C57BL/6N-Frrs1l^tm1a(EUCOMM)Hmgu/H	MGI:8158815

Genotype
MGI:8158815

ht1

• Allelic Composition: Frrs1l^{tm1a(EUCOMM)Hmgu}/Frrs1l⁺
• Genetic Background: C57BL/6N-Frrs1l^{tm1a(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0701_4_B11

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:361398 )

N • mice show normal levels of moving distance in the open field test indicating normal locomotor activity, normal thigmotaxis levels indicating no change in anxiety level, and no differences in the test for object location memory and in levels of freezing in the contextual fear memory test

decreased social novelty preference ( J:361398 )

• in the social novelty recognition test, mice exhibit no preference for a novel mouse over a familiar one and show a similar number of interactions to both the novel and familiar mouse

• however, in the three-chamber sociability test, mice show normal sociability preferring the interaction with a conspecific mouse and do not differ in social interest or motivation for social engagement