Analysis Tools|
Allele Symbol Allele Name Allele ID |
Lamc3tm1.1Wjbr targeted mutation 1.1, William J Brunken MGI:4941480 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P20, the perikarya of type I tyrosine hydroxylase expressing (TH) neurons are somewhat larger compared to wild-type controls
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• at P20, the perikarya of type I tyrosine hydroxylase expressing (TH) neurons are somewhat larger compared to wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P20 the basement membrane shows local disruptions in its structure
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• at the sites of breaks in the basement membrane, Muller cell basal terminals form a disorganized array from the inner plexiform layer (IPL) through the ganglion cell layer
• at other points, Muller cell terminals form aggregates at blood vessels
• the overall length is reduced and the fine lateral branches within the IPL are disarrayed
• at P12, the vertical shafts are thinner in the regions of basement membrane breaks
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• at P20, the perikarya of type I tyrosine hydroxylase expressing (TH) neurons are somewhat smaller compared to wild-type controls and both single null mice
• however, no abnormalities are detected in cholinergic or AII amacrine cells
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• decrease in the density of type I TH neurons at P20
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• the delay in the increase in density of type I TH neurons detected between P3 and P5 is increased compared to mice homozygous null for Lamb2 alone
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• the tyrosine hydroxylase immunoreactivity of type II amacrine cells is increased at P20
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• at the sites of breaks in the basement membrane, Muller cell basal terminals form a disorganized array from the inner plexiform layer (IPL) through the ganglion cell layer
• at other points, Muller cell terminals form aggregates at blood vessels
• the overall length is reduced and the fine lateral branches within the IPL are disarrayed
• at P12, the vertical shafts are thinner in the regions of basement membrane breaks
|
|
• at P20, the perikarya of type I tyrosine hydroxylase expressing (TH) neurons are somewhat smaller compared to wild-type controls and both single null mice
• however, no abnormalities are detected in cholinergic or AII amacrine cells
|
|
• decrease in the density of type I TH neurons at P20
|
|
• at the sites of breaks in the basement membrane, Muller cell basal terminals form a disorganized array from the inner plexiform layer (IPL) through the ganglion cell layer
• at other points, Muller cell terminals form aggregates at blood vessels
• the overall length is reduced and the fine lateral branches within the IPL are disarrayed
• at P12, the vertical shafts are thinner in the regions of basement membrane breaks
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/06/2026 MGI 6.24 |
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