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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srgap3tm1.1Ssod
targeted mutation 1.1, Scott H Soderling
MGI:4941459
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Srgap3tm1Ssod/Srgap3tm1.1Ssod
Tg(Thy1-cre/ERT2,-EYFP)VGfng/0 		involves: C57BL/6 * SJL MGI:4941466
cx2
 		Srgap3tm1.1Ssod/Srgap3tm1.1Ssod
Tg(Thy1-EGFP)OJrs/0 		involves: C57BL/6J * CBA MGI:4941464
cx3
 		Srgap3tm1.1Ssod/Srgap3+
Tg(Thy1-EGFP)OJrs/0 		involves: C57BL/6J * CBA MGI:4941465


Genotype
MGI:4941466
cn1
Allelic
Composition		 Srgap3tm1Ssod/Srgap3tm1.1Ssod
Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srgap3tm1.1Ssod mutation (0 available); any Srgap3 mutation (62 available)
Srgap3tm1Ssod mutation (0 available); any Srgap3 mutation (62 available)
Tg(Thy1-cre/ERT2,-EYFP)VGfng mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:169533 )
N
• tamoxifen-treated mice exhibit normal spine density




Genotype
MGI:4941464
cx2
Allelic
Composition		 Srgap3tm1.1Ssod/Srgap3tm1.1Ssod
Tg(Thy1-EGFP)OJrs/0
Genetic
Background		 involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srgap3tm1.1Ssod mutation (0 available); any Srgap3 mutation (62 available)
Tg(Thy1-EGFP)OJrs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendritic spine morphology ( J:169533 )
• mice exhibit reduction in spine densities in the CA1 and cortical layers IV/V compared to in wild-type mice




Genotype
MGI:4941465
cx3
Allelic
Composition		 Srgap3tm1.1Ssod/Srgap3+
Tg(Thy1-EGFP)OJrs/0
Genetic
Background		 involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srgap3tm1.1Ssod mutation (0 available); any Srgap3 mutation (62 available)
Tg(Thy1-EGFP)OJrs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendritic spine morphology ( J:169533 )
• the number of mushroom-shaped spines is reduced while thin spines are increased compared to in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory