Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(Pim1-E2F1)Rebr}
• Allele Name: targeted mutation 1, Rene Bernards
• Allele ID: MGI:4940857
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor^+ Tmem163^Tg(ACTB-cre)2Mrt/0	involves: 129P2/OlaHsd * FVB * FVB/N	MGI:4940865

Genotype
MGI:4940865

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Pim1-E2F1)Rebr}/Gt(ROSA)26Sor⁺; Tmem163^{Tg(ACTB-cre)2Mrt}/0
• Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:83303 )

• marginally fewer than expected mice are present at 3 weeks

skeleton

abnormal skeleton morphology ( J:83303 )

abnormal long bone epiphyseal plate proliferative zone ( J:83303 )

• the area of columnar proliferating chondrocytes is larger than in wild-type mice

decreased width of hypertrophic chondrocyte zone ( J:83303 )

• prehypertrophic and hypertrophic zones are reduced in size compared to in wild-type mice

growth/size/body

decreased body size ( J:83303 )

postnatal growth retardation ( J:83303 )

• in 2 of 30 mice