Phenotypes associated with this allele

• Allele Symbol: Nlgn3^tm3.1Sud
• Allele Name: targeted mutation 3.1, Thomas C Sudhof
• Allele ID: MGI:4940407
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlgn3^tm3.1Sud/Nlgn3^tm3.1Sud	involves: 129S1/Sv * 129X1/SvJ	MGI:5320585

Genotype
MGI:5320585

hm1

• Allelic Composition: Nlgn3^tm3.1Sud/Nlgn3^tm3.1Sud
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:184114 )

♀N • mice exhibit normal synapse density and size, miniature inhibitory postsynaptic currents and presynaptic release probability

abnormal excitatory postsynaptic potential ( J:184114 )

♀ • mice exhibit decreased evoked excitatory synaptic strength compared with wild-type mice

abnormal glutamate-mediated receptor currents ( J:184114 )

♀ • mice exhibit an increase in the NMDA to AMPA receptor mediated synaptic transmission ratio compared with wild-type mice

♀ • however, mice exhibit normal NMDA receptor-dependent long term potentiation and GABA receptor-mediated synaptic response

reduced AMPA-mediated synaptic currents ( J:184114 )

♀

abnormal miniature excitatory postsynaptic currents ( J:184114 )

♀ • decreased frequency but not amplitude