Phenotypes associated with this allele

• Allele Symbol: Elovl2^tm1Jaco
• Allele Name: targeted mutation 1, Anders Jacobsson
• Allele ID: MGI:4939584
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elovl2^tm1Jaco/Elovl2^tm1Jaco	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4939586
ht2	Elovl2^tm1Jaco/Elovl2^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4939585

Genotype
MGI:4939586

hm1

• Allelic Composition: Elovl2^tm1Jaco/Elovl2^tm1Jaco
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:168856 )

N • female mice exhibit normal fertility

decreased testis weight ( J:168856 )

♂

arrest of spermatogenesis ( J:168856 )

♂ • primary spermatocytes degenerate

male infertility ( J:168856 )

♂

homeostasis/metabolism

decreased fatty acids level ( J:168856 )

• mice exhibit reduced n-3 and n-6 fatty acid serum levels compared to in wild-type mice

endocrine/exocrine glands

decreased testis weight ( J:168856 )

♂

Genotype
MGI:4939585

ht2

• Allelic Composition: Elovl2^tm1Jaco/Elovl2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

reproductive system

teratozoospermia ( J:168856 )

♂

abnormal sperm head morphology ( J:168856 )

♂ • sperm exhibit rounded, condensed heads with small rounded vacuoles unlike in wild-type cells

reduced male fertility ( J:168856 )

♂

cellular

teratozoospermia ( J:168856 )

♂

abnormal sperm head morphology ( J:168856 )

♂ • sperm exhibit rounded, condensed heads with small rounded vacuoles unlike in wild-type cells