Phenotypes associated with this allele

• Allele Symbol: Mrpl3^dcr
• Allele Name: decrepit
• Allele ID: MGI:4938306
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrpl3^dcr/Mrpl3^dcr	B6(Cg)-Mrpl3^dcr/Dcr	MGI:4938628

Genotype
MGI:4938628

hm1

• Allelic Composition: Mrpl3^dcr/Mrpl3^dcr
• Genetic Background: B6(Cg)-Mrpl3^dcr/Dcr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:167846 )

• mice die between 18 and 22 weeks

nervous system

increased susceptibility to ischemic brain injury ( J:167846 )

• mice exhibit adult-onset focal ischemia unlike wild-type mice

brain vacuoles ( J:167846 )

• in the ventral cortex

astrocytosis ( J:167846 )

• in the striatum

neurodegeneration ( J:167846 , J:289566 )

• progressive (J:167846)

hippocampal neuron degeneration ( J:289566 )

behavior/neurological

lethargy ( J:167846 )

• after 10 weeks

impaired learning ( J:289566 )

• impaired performance in the Barnes maze shows a deficit in learning in the adult homozygote, but they can learn

impaired spatial learning ( J:289566 )

hunched posture ( J:167846 )

• at 10 weeks

nervous ( J:167846 )

• after 10 weeks

growth/size/body

cachexia ( J:167846 )

• at 12 weeks

integument

disheveled coat ( J:167846 )

• at 10 weeks, mice look unkempt and scruffy compared with wild-type mice

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:167846 )

• mice exhibit adult-onset focal ischemia unlike wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:167846 )

N • mice do not exhibit hemorrhage, embolism, or abnormalities in cerebral vasculature