Phenotypes associated with this allele

• Allele Symbol: Mtor^tm1Lgm
• Allele Name: targeted mutation 1, Laboratory of Genetics
• Allele ID: MGI:4889219
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtor^tm1Lgm/Mtor^tm1Lgm	involves: 129S1/Sv * C57BL/6	MGI:4889223

Genotype
MGI:4889223

hm1

• Allelic Composition: Mtor^tm1Lgm/Mtor^tm1Lgm
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:168600 )

• fewer than expected mice are produced

immune system

decreased splenocyte apoptosis ( J:168600 )

• following stimulation with anti-CD3 anti-CD28 antibodies

decreased splenocyte proliferation ( J:168600 )

• following stimulation with anti-CD3 anti-CD28 antibodies

abnormal B cell differentiation ( J:168600 )

• mice exhibit a partial block to B cell development compared with wild-type mice

decreased transitional stage T1 B cell number ( J:168600 )

decreased neutrophil cell number ( J:168600 )

• in the spleen

decreased B cell number ( J:168600 )

• in the spleen and bone marrow

decreased follicular B cell number ( J:168600 )

decreased marginal zone B cell number ( J:168600 )

decreased plasma cell number ( J:168600 )

• in the spleen

decreased monocyte cell number ( J:168600 )

• in the spleen

abnormal T cell morphology ( J:168600 )

• single positive T cells are smaller than in wild-type mice

decreased thymocyte number ( J:168600 )

• in the thymus and spleen

decreased double-positive T cell number ( J:168600 )

• in the thymus and spleen

increased CD4-positive, alpha-beta T cell number ( J:168600 )

• in the thymus and spleen

increased CD8-positive, alpha-beta T cell number ( J:168600 )

• in the thymus and spleen

small spleen ( J:168600 )

abnormal B cell physiology ( J:168600 )

• splenic B cell migration in response to CXCL12 and S1P is decreased compared with wild-type cells

decreased B cell proliferation ( J:168600 )

• following BCR or TCR stimulation

decreased IgG level ( J:168600 )

• following T-dependent and T-independent stimulation

decreased IgM level ( J:168600 )

• following T-dependent and T-independent stimulation

abnormal T cell physiology ( J:168600 )

• thymic T cells exhibit defects in migration in response to CCL25 and CXCL12 compared with wild-type cells

• however, migratory response to CCL19 is normal

abnormal humoral immune response ( J:168600 )

• mice exhibit reduced antibody production in response to both T-dependent and T-independent stimulation compared with similarly treated wild-type mice

growth/size/body

decreased body size ( J:168600 )

decreased body weight ( J:168600 )

hematopoietic system

decreased splenocyte apoptosis ( J:168600 )

• following stimulation with anti-CD3 anti-CD28 antibodies

decreased splenocyte proliferation ( J:168600 )

• following stimulation with anti-CD3 anti-CD28 antibodies

abnormal B cell differentiation ( J:168600 )

• mice exhibit a partial block to B cell development compared with wild-type mice

decreased transitional stage T1 B cell number ( J:168600 )

decreased neutrophil cell number ( J:168600 )

• in the spleen

decreased B cell number ( J:168600 )

• in the spleen and bone marrow

decreased follicular B cell number ( J:168600 )

decreased marginal zone B cell number ( J:168600 )

decreased plasma cell number ( J:168600 )

• in the spleen

decreased monocyte cell number ( J:168600 )

• in the spleen

abnormal T cell morphology ( J:168600 )

• single positive T cells are smaller than in wild-type mice

decreased thymocyte number ( J:168600 )

• in the thymus and spleen

decreased double-positive T cell number ( J:168600 )

• in the thymus and spleen

increased CD4-positive, alpha-beta T cell number ( J:168600 )

• in the thymus and spleen

increased CD8-positive, alpha-beta T cell number ( J:168600 )

• in the thymus and spleen

small spleen ( J:168600 )

abnormal B cell physiology ( J:168600 )

• splenic B cell migration in response to CXCL12 and S1P is decreased compared with wild-type cells

decreased B cell proliferation ( J:168600 )

• following BCR or TCR stimulation

decreased IgG level ( J:168600 )

• following T-dependent and T-independent stimulation

decreased IgM level ( J:168600 )

• following T-dependent and T-independent stimulation

abnormal T cell physiology ( J:168600 )

• thymic T cells exhibit defects in migration in response to CCL25 and CXCL12 compared with wild-type cells

• however, migratory response to CCL19 is normal

cellular

decreased splenocyte apoptosis ( J:168600 )

• following stimulation with anti-CD3 anti-CD28 antibodies

decreased B cell proliferation ( J:168600 )

• following BCR or TCR stimulation

decreased splenocyte proliferation ( J:168600 )

• following stimulation with anti-CD3 anti-CD28 antibodies

endocrine/exocrine glands

decreased thymocyte number ( J:168600 )

• in the thymus and spleen