Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac3tm1.1Laz mutation
(1 available);
any
Hdac3 mutation
(31 available)
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behavior/neurological
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• 2 weeks after bilateral intrahippocampal infusion of adenoviral cre mice display enhanced long term memory for object location, forming memories following a 3 min training period that persist for up to 7 days
• however, no difference is detected in novel object recognition
• treatment with an siRNA for Nr4a2 blocks enhanced memory formation in adenoviral cre treated mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac3tm1.1Laz mutation
(1 available);
any
Hdac3 mutation
(31 available)
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liver/biliary system
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• hepatosteatosis without obvious inflammation in mice injected with adenovirus expressing cre in the liver
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac3tm1.1Laz mutation
(1 available);
any
Hdac3 mutation
(31 available)
Tg(Fabp4-cre)1Rev mutation
(2 available)
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mortality/aging
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• no viable adults are obtained; mice are born at the expected Mendelian ratio, but none survive beyond 25 days of age
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• more than 50% die before postnatal day 5 (P5); remaining animals display failure to thrive and a wasting phenotype
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growth/size/body
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• animals surviving past P5 fail to thrive and display a wasting phenotype
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac3tm1.1Laz mutation
(1 available);
any
Hdac3 mutation
(31 available)
Tg(Retn-cre)1Laz mutation
(0 available)
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normal phenotype
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• mice show no overt abnormalities and survive until adulthood
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac3tm1.1Laz mutation
(1 available);
any
Hdac3 mutation
(31 available)
Tg(Adipoq-cre)1Evdr mutation
(3 available)
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mortality/aging
N |
• mice show no reduction in survival to at least 6 months
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