Phenotypes associated with this allele

• Allele Symbol: Gnao1^tm2Lbi
• Allele Name: targeted mutation 2, Lutz Birnbaumer
• Allele ID: MGI:4889046
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnao1^tm2Lbi/Gnao1^tm2Lbi	involves: 129S7/SvEvBrd	MGI:4889053

Genotype
MGI:4889053

hm1

• Allelic Composition: Gnao1^tm2Lbi/Gnao1^tm2Lbi
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal survival ( J:168245 )

• most but not all die before adulthood

• born in normal numbers

behavior/neurological

tremors ( J:168245 )

abnormal locomotor behavior ( J:168245 )

• abnormal turning behavior

• impaired locomotion

vision/eye

abnormal eye electrophysiology ( J:168245 )

• lack ERG b-waves from outer nuclear layer bipolar cells

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:168245 )

N • normal glucose tolerance tests

N • peak blood glucose levels at 10-20 minutes and back to baseline at 150 minutes