Phenotypes associated with this allele

• Allele Symbol: Sfn^tm1Mak
• Allele Name: targeted mutation 1, Tak Mak
• Allele ID: MGI:4888527
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sfn^tm1Mak/Sfn^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:4888545

Genotype
MGI:4888545

hm1

• Allelic Composition: Sfn^tm1Mak/Sfn^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:168328 )

• in vesicular stomatitis virus (VSV)-infected mice

immune system

immune system phenotype ( J:168328 )

N • mice exhibit normal T cell dependent immune response

increased B cell apoptosis ( J:168328 )

• when cells are used in adoptive transfer experiments in Rag1 null mice

increased B cell proliferation ( J:168328 )

• in uninduced and BCR-stimulated mice

abnormal B cell differentiation ( J:168328 )

• adoptive transfer experiments confirm that the defects in B cell homeostasis is B cell intrinsic

decreased B cell number ( J:168328 )

• recirculating B cells are decreased compared to in wild-type mice

• splenic B cells are decreased compared to in wild-type mice

decreased B-1a cell number ( J:168328 )

decreased follicular B cell number ( J:168328 )

abnormal spleen morphology ( J:168328 )

• the splenic B cell zone is smaller, the T cell zone is not consistently surrounded by B cells, the follicular B cell area is smaller, and the marginal zone B cell area is absent compared to in wild-type mice

decreased marginal zone B cell number ( J:168328 )

abnormal spleen B cell follicle morphology ( J:168328 )

• decreased

absent spleen marginal zone ( J:168328 )

decreased IgG level ( J:168328 )

• in vesicular stomatitis virus (VSV)-infected mice

decreased IgM level ( J:168328 )

• following TNP-Ficoll injection

increased susceptibility to Riboviria infection ( J:168328 )

• vesicular stomatitis virus (VSV)-infected mice exhibit decreased IgG levels and increased mortality compared with similarly treated wild-type mice

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:168328 )

• in vesicular stomatitis virus (VSV)-infected mice

hematopoietic system

increased B cell apoptosis ( J:168328 )

• when cells are used in adoptive transfer experiments in Rag1 null mice

increased B cell proliferation ( J:168328 )

• in uninduced and BCR-stimulated mice

abnormal B cell differentiation ( J:168328 )

• adoptive transfer experiments confirm that the defects in B cell homeostasis is B cell intrinsic

decreased B cell number ( J:168328 )

• recirculating B cells are decreased compared to in wild-type mice

• splenic B cells are decreased compared to in wild-type mice

decreased B-1a cell number ( J:168328 )

decreased follicular B cell number ( J:168328 )

abnormal spleen morphology ( J:168328 )

• the splenic B cell zone is smaller, the T cell zone is not consistently surrounded by B cells, the follicular B cell area is smaller, and the marginal zone B cell area is absent compared to in wild-type mice

decreased marginal zone B cell number ( J:168328 )

abnormal spleen B cell follicle morphology ( J:168328 )

• decreased

absent spleen marginal zone ( J:168328 )

decreased IgG level ( J:168328 )

• in vesicular stomatitis virus (VSV)-infected mice

decreased IgM level ( J:168328 )

• following TNP-Ficoll injection

cellular

increased B cell apoptosis ( J:168328 )

• when cells are used in adoptive transfer experiments in Rag1 null mice

increased B cell proliferation ( J:168328 )

• in uninduced and BCR-stimulated mice