Phenotypes associated with this allele

• Allele Symbol: Slco2a1^tm1Vsch
• Allele Name: targeted mutation 1, Victor L Schuster
• Allele ID: MGI:4888398
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slco2a1^tm1Vsch/Slco2a1^tm1Vsch	involves: 129S6/SvEvTac * C57BL/6J	MGI:4888411

Genotype
MGI:4888411

hm1

• Allelic Composition: Slco2a1^tm1Vsch/Slco2a1^tm1Vsch
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:168442 )

• no mice survive beyond P2

cardiovascular system

patent ductus arteriosus ( J:168442 )

• after birth, the ductus arteriosus exhibits a single endothelial layer with an open lumen covered by layers of normal intimal thickening unlike in wild-type mice

• however, the ductus arteriosus is normal before birth

dilated heart left ventricle ( J:168442 )

• in mice that die on P1

dilated heart right ventricle ( J:168442 )

• in mice that die on P1

cellular

patent ductus arteriosus ( J:168442 )

• after birth, the ductus arteriosus exhibits a single endothelial layer with an open lumen covered by layers of normal intimal thickening unlike in wild-type mice

• however, the ductus arteriosus is normal before birth