Phenotypes associated with this allele

• Allele Symbol: Tg(Col1a1-Runx2)#Pmt
• Allele Name: transgene insertion, Patrick Matthias
• Allele ID: MGI:4887925
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Col1a1-Runx2)#Pmt/0 Tg(Eno2tTA)#Nes/0 Tg(tetO-Zfp521)#Rbar/0	involves: BALB/c * C57BL/6 * SJL	MGI:4887975
tg2	Tg(Col1a1-Runx2)#Pmt/0	involves: BALB/c * C57BL/6	MGI:4887974

Genotype
MGI:4887975

cx1

• Allelic Composition: Tg(Col1a1-Runx2)#Pmt/0; Tg(Eno2tTA)#Nes/0; Tg(tetO-Zfp521)#Rbar/0
• Genetic Background: involves: BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:167992 )

N • nearly all aspects of the Tg(Col1a1-Runx2)#Pmt phenotype are reversed

decreased compact bone thickness ( J:167992 )

decreased osteocyte number ( J:167992 )

• osteocyte numbers in the cortical bone are reduced compared to in wild-type mice but not as severely as in Tg(Col1a1-Runx2)#Pmt mice

abnormal bone mineralization ( J:167992 )

• mice exhibit reduced cortical mineral apposition rates compared with wild-type mice

fragile skeleton ( J:167992 )

• fracture rate is increased compared to in wild-type mice but not as severely as in Tg(Col1a1-Runx2)#Pmt mice

Genotype
MGI:4887974

tg2

• Allelic Composition: Tg(Col1a1-Runx2)#Pmt/0
• Genetic Background: involves: BALB/c * C57BL/6

skeleton

abnormal osteoblast differentiation ( J:167992 )

• mice exhibit impaired osteoblast maturation compared with wild-type mice

increased osteoclast cell number ( J:167992 )

• in the trabecular bone

abnormal compact bone morphology ( J:167992 )

• the cortices are highly porous unlike in wild-type mice

decreased compact bone thickness ( J:167992 )

increased osteoblast cell number ( J:167992 )

• in the trabecular bone

decreased osteocyte number ( J:167992 )

• osteocyte numbers in the cortical bone are reduced compared to in wild-type mice

decreased bone mass ( J:167992 )

abnormal bone ossification ( J:167992 )

• bone formation rate is reduced compared to in wild-type mice

abnormal bone mineralization ( J:167992 )

• mice exhibit reduced cortical mineral apposition rates compared with wild-type mice

fragile skeleton ( J:167992 )

immune system

increased osteoclast cell number ( J:167992 )

• in the trabecular bone

hematopoietic system

increased osteoclast cell number ( J:167992 )

• in the trabecular bone

cellular

abnormal osteoblast differentiation ( J:167992 )

• mice exhibit impaired osteoblast maturation compared with wild-type mice