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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dpy30tm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4887610
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dpy30tm1a(KOMP)Wtsi/Dpy30tm1a(KOMP)Wtsi C57BL/6N-Dpy30tm1a(KOMP)Wtsi/Wtsi MGI:5631076
ht2
 		Dpy30tm1a(KOMP)Wtsi/Dpy30+ C57BL/6N-Dpy30tm1a(KOMP)Wtsi/Wtsi MGI:5705990


Genotype
MGI:5631076
hm1
Allelic
Composition		 Dpy30tm1a(KOMP)Wtsi/Dpy30tm1a(KOMP)Wtsi
Genetic
Background		 C57BL/6N-Dpy30tm1a(KOMP)Wtsi/Wtsi
Cell Lines EPD0714_4_B05
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpy30tm1a(KOMP)Wtsi mutation (1 available); any Dpy30 mutation (45 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal gastrulation ( J:221596 )
• impaired gastrulation of the pluripotent epiblast
abnormal mesendoderm development ( J:221596 )
• mesendoderm specification is blocked at E6.5, as shown by failure to properly induce mesendoderm markers (Eomes, Gsc, and Brachyury)
abnormal rostral-caudal axis patterning ( J:221596 )
• no clear anterior-posterior patterning at E6.5
embryonic growth retardation ( J:221596 )
• developmental delay at E7.5
abnormal embryonic epiblast morphology ( J:221596 )
• prematurely reduced expression of pluripotency epiblast markers (Nanog, Pou5f1/Oct4, Sox2) at E6.5
abnormal embryonic neuroepithelium morphology ( J:221596 )
• expression of neuroectoderm markers is either unaffected (Sox2 and Sox1) or even increased (Dlx5 and Hesx1) at E6.5
failure of primitive streak formation ( J:221596 )
• failure to properly induce primitive streak markers (Eomes, Gsc, and Brachyury) at E6.5

growth/size/body
embryonic growth retardation ( J:221596 )
• developmental delay at E7.5
decreased embryo size ( J:221596 )
• at E6.5

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:221596 )
• homozygotes die between E7.5 and E9.5; no homozygotes are recovered at E9.5

nervous system
abnormal embryonic neuroepithelium morphology ( J:221596 )
• expression of neuroectoderm markers is either unaffected (Sox2 and Sox1) or even increased (Dlx5 and Hesx1) at E6.5




Genotype
MGI:5705990
ht2
Allelic
Composition		 Dpy30tm1a(KOMP)Wtsi/Dpy30+
Genetic
Background		 C57BL/6N-Dpy30tm1a(KOMP)Wtsi/Wtsi
Cell Lines EPD0714_4_B05
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpy30tm1a(KOMP)Wtsi mutation (1 available); any Dpy30 mutation (45 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory