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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hbs1ltm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4887599
Summary 2 genotypes


Genotype
MGI:5700912
hm1
Allelic
Composition		 Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)Wtsi
Genetic
Background		 C57BL/6N-Hbs1ltm1a(KOMP)Wtsi/Wtsi
Cell Lines EPD0693_2_A02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbs1ltm1a(KOMP)Wtsi mutation (3 available); any Hbs1l mutation (51 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue

craniofacial
abnormal facial morphology ( J:272028 )
• mice exhibit abnormal facial structure that is more prevalent in females than males
abnormal tooth morphology ( J:272028 )
• dental asymmetry
abnormal nasal bone morphology ( J:272028 )
• 86% of females exhibit depressed nasal bones compared to 43% of males
short nasal bone ( J:272028 )
• 86% of females exhibit shortened nasal bones compared to 14% of males
abnormal zygomatic bone morphology ( J:272028 )
• depressed zygomatic bones

growth/size/body
abnormal facial morphology ( J:272028 )
• mice exhibit abnormal facial structure that is more prevalent in females than males
abnormal tooth morphology ( J:272028 )
• dental asymmetry
malocclusion ( J:272028 )
abnormal nasal bone morphology ( J:272028 )
• 86% of females exhibit depressed nasal bones compared to 43% of males
short nasal bone ( J:272028 )
• 86% of females exhibit shortened nasal bones compared to 14% of males
abnormal zygomatic bone morphology ( J:272028 )
• depressed zygomatic bones
abnormal snout morphology ( J:211773 )
IMPC - WTSI
asymmetric snout ( J:272028 )
short snout ( J:272028 )
decreased body weight ( J:272028 )
• mice weigh less at various ages

hematopoietic system
thrombocytosis ( J:211773 )
IMPC - WTSI

homeostasis/metabolism

immune system

limbs/digits/tail

pigmentation
abnormal retina pigmentation ( J:272028 )
• atypical retinal pigmentation

reproductive system
male infertility ( J:211773 , J:272028 )
IMPC - WTSI (J:211773)
MGI (J:272028)

respiratory system
abnormal nasal bone morphology ( J:272028 )
• 86% of females exhibit depressed nasal bones compared to 43% of males
short nasal bone ( J:272028 )
• 86% of females exhibit shortened nasal bones compared to 14% of males

skeleton
abnormal tooth morphology ( J:272028 )
• dental asymmetry
abnormal nasal bone morphology ( J:272028 )
• 86% of females exhibit depressed nasal bones compared to 43% of males
short nasal bone ( J:272028 )
• 86% of females exhibit shortened nasal bones compared to 14% of males
abnormal zygomatic bone morphology ( J:272028 )
• depressed zygomatic bones
abnormal vertebrae morphology ( J:272028 )
• vertebral defects such as transitional vertebrae and abnormal shape
vertebral transformation ( J:211773 , J:272028 )
IMPC - WTSI (J:211773)

vision/eye
cornea opacity ( J:211773 )
IMPC - WTSI
abnormal retina pigmentation ( J:272028 )
• atypical retinal pigmentation




Genotype
MGI:6718851
hm2
Allelic
Composition		 Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)Wtsi
Genetic
Background		 C57BL/6NTac-Hbs1ltm1a(KOMP)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbs1ltm1a(KOMP)Wtsi mutation (3 available); any Hbs1l mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
oligozoospermia ( J:306384 )
• no mice are recovered at E6.5

reproductive system
oligozoospermia ( J:306384 )
• no mice are recovered at E6.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory