Phenotypes associated with this allele

• Allele Symbol: Hkdc1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4887590
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hkdc1^tm1a(KOMP)Wtsi/Hkdc1^tm1a(KOMP)Wtsi	involves: C57BL/6N	MGI:5912280
ht2	Hkdc1^tm1a(KOMP)Wtsi/Hkdc1^+	involves: C57BL/6N	MGI:5912281

Genotype
MGI:5912280

hm1

• Allelic Composition: Hkdc1^{tm1a(KOMP)Wtsi}/Hkdc1^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0846_5_B10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:240354 )

• no mice are produced from mating heterozygotes

Genotype
MGI:5912281

ht2

• Allelic Composition: Hkdc1^{tm1a(KOMP)Wtsi}/Hkdc1⁺
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0846_5_B10

cellular

decreased cellular glucose uptake ( J:240354 )

• 120 minutes after a glucose challenge with a bolus of labeled glucose, a reduced quantity of labelled glucose was present in tissue from heterozygous mice, especially in the small intestine, with a trend toward lower levels in the other tissues

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:240354 )

N • mice exhibit normal insulin secretion, insulin sensitivity, gluconeogenesis and metabolic phenotype

impaired glucose tolerance ( J:240354 )

• in female and male mice at 28 weeks of age

• in pregnant mice at 15 days gestation

decreased liver triglyceride level ( J:240354 )

♀ • in female mice with lower trends in male mice

liver/biliary system

decreased liver triglyceride level ( J:240354 )

♀ • in female mice with lower trends in male mice