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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdc20tm1.2Mama
targeted mutation 1.2, Marcos Malumbres
MGI:4887574
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdc20tm1.2Mama/Cdc20tm1.2Mama involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL MGI:4887577
cn2
 		Cdc20tm1.1Mama/Cdc20tm1.2Mama
Polr2atm1(cre/ERT2)Bbd/Polr2a+ 		involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL MGI:4887575


Genotype
MGI:4887577
hm1
Allelic
Composition		 Cdc20tm1.2Mama/Cdc20tm1.2Mama
Genetic
Background		 involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc20tm1.2Mama mutation (0 available); any Cdc20 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
failure of zygotic cell division ( J:167609 )
• by E1.5, cells arrest in metaphase with abnormal mitotic figures unlike in control embryos




Genotype
MGI:4887575
cn2
Allelic
Composition		 Cdc20tm1.1Mama/Cdc20tm1.2Mama
Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic
Background		 involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc20tm1.1Mama mutation (1 available); any Cdc20 mutation (30 available)
Cdc20tm1.2Mama mutation (0 available); any Cdc20 mutation (30 available)
Polr2atm1(cre/ERT2)Bbd mutation (3 available); any Polr2a mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:167609 )
• after 8 to 10 days on a tamoxifen diet
• however, survival is increased when older mice (1 year old) are treated with tamoxifen

cellular
abnormal mitosis ( J:167609 )
• tamoxifen-treated mice exhibit widespread metaphase arrest in proliferative areas of the intestine and testis unlike in control mice
• topical treatment results in metaphase figures in the basal layer and in the hair follicle cells in depilated mice compared to in similarly treated control mice
decreased cell proliferation ( J:167609 )
• tamoxifen-treated mice exhibit reduced proliferation in the testis and spleen compared with control mice

neoplasm
decreased tumor growth/size ( J:167609 )
• in a two-stage carcinogenesis protocol, tamoxifen-treated mice exhibit tumor arrest unlike similarly treated control mice
tumor regression ( J:167609 )
• in tamoxifen-treated mice

integument
delayed hair regrowth ( J:167609 )
• following topical application of tamoxifen, depilated mice exhibit impaired hair regeneration compared with similarly treated control mice
abnormal epidermis stratum basale morphology ( J:167609 )
• topical treatment results in metaphase figures in the basal layer compared to in similarly treated control mice

digestive/alimentary system
abnormal intestinal epithelium morphology ( J:167609 )
• tamoxifen-treated mice exhibit loss of intestinal epithelium unlike in control mice

growth/size/body
weight loss ( J:167609 )
• in tamoxifen-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory