Phenotypes associated with this allele

• Allele Symbol: Gpr34^tm1.1Shbg
• Allele Name: targeted mutation 1.1, Torsten Schoneberg
• Allele ID: MGI:4887271
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr34^tm1.1Shbg/Gpr34^tm1.1Shbg	B6.Cg-Gpr34^tm1.1Shbg	MGI:4887441

Genotype
MGI:4887441

hm1

• Allelic Composition: Gpr34^tm1.1Shbg/Gpr34^tm1.1Shbg
• Genetic Background: B6.Cg-Gpr34^tm1.1Shbg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:168120 )

♀ • peritoneal monocytes exhibit a 1.8-fold increase in basal migration compared with wild-type cells

increased susceptibility to type IV hypersensitivity reaction ( J:168120 )

♀ • in a delayed hypersensitivity tests, mice exhibit increased footpad swelling and cytokine production (TNF-alpha, IFN-gamma, GM-CSF, IL2, IL4, IL5, IL10, and IL12 when non-stimulated; TNF-alpha, IFN-gamma, IL2, IL5, and IL-10 when mBSA-stimulated) in spleen cells compared with wild-type mice

abnormal cytokine secretion ( J:168120 )

♀

abnormal chemokine secretion ( J:168120 )

♀ • in a delayed-hypersensitivity test with or without mBAS-stimulation or Cryptococcus neoformans-infected mice with hiCap stimulation, mice exhibit increased GM-CSF production from spleen cells compared with wild-type mice

increased interferon-gamma secretion ( J:168120 )

♀ • in a delayed-hypersensitivity test without stimulation

♀ • in Cryptococcus neoformans-infected mice

increased interleukin-10 secretion ( J:168120 )

♀ • in a delayed-hypersensitivity test without stimulation

♀ • in Cryptococcus neoformans-infected mice with or without hiCap stimulation

increased interleukin-12 secretion ( J:168120 )

♀ • in a delayed-hypersensitivity test with mBAS-stimulation

♀ • in Cryptococcus neoformans-infected mice with hiCap stimulation

increased interleukin-2 secretion ( J:168120 )

♀ • in a delayed-hypersensitivity test with or without mBAS-stimulation

♀ • in Cryptococcus neoformans-infected mice with or without hiCap stimulation

increased interleukin-4 secretion ( J:168120 )

♀ • in a delayed-hypersensitivity test with or without mBAS-stimulation

♀ • in Cryptococcus neoformans-infected mice with or without hiCap stimulation

increased interleukin-5 secretion ( J:168120 )

♀ • in a delayed-hypersensitivity test with or without mBAS-stimulation

♀ • in Cryptococcus neoformans-infected mice with or without hiCap stimulation

increased tumor necrosis factor secretion ( J:168120 )

♀ • in a delayed-hypersensitivity test with or without mBAS-stimulation

♀ • in Cryptococcus neoformans-infected mice with or without hiCap stimulation

increased susceptibility to fungal infection ( J:168120 )

♀ • Cryptococcus neoformans-infected mice exhibit higher pathogen burden in the lung, spleen, and brain and higher cytokine concentrations (TNF-alpha, IFN-gamma, GM-CSF, IL2, IL4, IL5, IL10, and IL12 when non-stimulated; TNF-alpha, GM-CSF, IL2, IL4, IL5, and IL12 when hiCap-stimulated) in spleen cells compared with wild-type mice

♀ • however, mortality is normal

nervous system

abnormal CNS glial cell morphology ( J:168120 )

♀ • in response to hypo-osmotic challenge, retinal glial and Muller cells exhibit increased cell swelling compared with wild-type mice

abnormal Muller cell morphology ( J:168120 )

♀ • in response to hypo-osmotic challenge, retinal glial and Muller cells exhibit increased cell swelling compared with wild-type mice

vision/eye

abnormal Muller cell morphology ( J:168120 )

♀ • in response to hypo-osmotic challenge, retinal glial and Muller cells exhibit increased cell swelling compared with wild-type mice

cellular

abnormal leukocyte migration ( J:168120 )

♀ • peritoneal monocytes exhibit a 1.8-fold increase in basal migration compared with wild-type cells

hematopoietic system

abnormal leukocyte migration ( J:168120 )

♀ • peritoneal monocytes exhibit a 1.8-fold increase in basal migration compared with wild-type cells