Phenotypes associated with this allele

• Allele Symbol: Cacna2d3^tm1Pngr
• Allele Name: targeted mutation 1, Josef M Penninger
• Allele ID: MGI:4887240
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna2d3^tm1Pngr/Cacna2d3^tm1Pngr	involves: 129P2/OlaHsd * C57BL/6	MGI:4887241

Genotype
MGI:4887241

hm1

• Allelic Composition: Cacna2d3^tm1Pngr/Cacna2d3^tm1Pngr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:167904 )

N • no defects in locomotor activity or mechanical pain sensitivity are detected

abnormal nociception after inflammation ( J:167904 )

• delayed thermal sensitization in the Complete Freund's Adjuvant (CFA) model of peripheral inflammatory pain

increased thermal nociceptive threshold ( J:167904 )

• defect in thermal nociception at 50, 52, 54, and 56 degrees C

nervous system

abnormal nervous system physiology ( J:167904 )

• noxious heat stimulation or vibrissal stimulation trigger enhanced activation of the visual and auditory cortexes as well as olfactory brain regions