All Phenotypes Gys1<tm1.1Arte> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gys1^tm1.1Arte
targeted mutation 1.1, TaconicArtemis
MGI:4882117

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gys1^tm1.1Arte/Gys1^tm1.1Arte	involves: C57BL/6J	MGI:4882128
ht2	Gys1^tm1.1Arte/Gys1⁺	involves: C57BL/6J	MGI:4882129
cx3	Gsk3a^tm1Dral/Gsk3a^tm1Dral Gsk3b^tm1Dral/Gsk3b^tm1Dral Gys1^tm1.1Arte/Gys1^tm1.1Arte	involves: 129P2/OlaHsd * C57BL/6J	MGI:4882130

Allelic Composition	Gys1^tm1.1Arte/Gys1^tm1.1Arte
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gys1^tm1.1Arte mutation (0 available); any Gys1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:167911 )

N	• mice exhibit normal whole-body glucose disposal and insulin sensitivity

abnormal glycogen homeostasis ( J:167911 )

• in the absence of insulin, glycogen synthesis is decreased compared to in wild-type mice

• insulin-stimulated glycogen synthesis is decreased 4-fold compared to in wild-type mice

increased glycogen catabolism rate ( J:167911 )

• both resting and insulin-stimulated (2.5-fold) in muscles

decreased skeletal muscle glycogen level ( J:167911 )

• under fed and fasting states

growth/size/body

growth/size/body region phenotype ( J:167911 )

N	• mice exhibit normal body mass

muscle

abnormal muscle cell glucose uptake ( J:167911 )

• insulin stimulation fails to increase glucose uptake in muscles unlike in similarly treated wild-type mice

• however, basal glucose uptake is normal

decreased skeletal muscle glycogen level ( J:167911 )

• under fed and fasting states

cellular

abnormal muscle cell glucose uptake ( J:167911 )

• insulin stimulation fails to increase glucose uptake in muscles unlike in similarly treated wild-type mice

• however, basal glucose uptake is normal

Allelic Composition	Gys1^tm1.1Arte/Gys1⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gys1^tm1.1Arte mutation (0 available); any Gys1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glycogen homeostasis ( J:167911 )

• in the absence of insulin, glycogen synthesis is decreased compared to in wild-type mice

• insulin-stimulated glycogen synthesis is decreased 2-fold compared to in wild-type mice

decreased skeletal muscle glycogen level ( J:167911 )

• under fed and fasting states

muscle

decreased skeletal muscle glycogen level ( J:167911 )

• under fed and fasting states

Allelic Composition	Gsk3a^tm1Dral/Gsk3a^tm1Dral Gsk3b^tm1Dral/Gsk3b^tm1Dral Gys1^tm1.1Arte/Gys1^tm1.1Arte
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3a^tm1Dral mutation (2 available); any Gsk3a mutation (18 available)
Gsk3b^tm1Dral mutation (1 available); any Gsk3b mutation (110 available)
Gys1^tm1.1Arte mutation (0 available); any Gys1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glycogen homeostasis ( J:167911 )

• insulin-stimulated glycogen synthesis is decreased compared to in wild-type mice and Gys1^tm1.1Arte homozygotes

• however, insulin treatment still results in an increase in glycogen synthesis

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