Phenotypes associated with this allele

• Allele Symbol: Nxn^tm1Hmik
• Allele Name: targeted mutation 1, Hiroaki Miki
• Allele ID: MGI:4881787
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nxn^tm1Hmik/Nxn^tm1Hmik	involves: 129P2/OlaHsd * C57BL/6J	MGI:4881804

Genotype
MGI:4881804

hm1

• Allelic Composition: Nxn^tm1Hmik/Nxn^tm1Hmik
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:167570 )

skeleton

small frontal bone ( J:167570 )

abnormal sternum morphology ( J:167570 )

• at P0

split xiphoid process ( J:167570 )

increased osteoblast cell number ( J:167570 )

• from calvaria cells in differentiation media

cardiovascular system

persistent truncus arteriosus ( J:167570 )

atrioventricular septal defect ( J:167570 )

ventricular septal defect ( J:167570 )

growth/size/body

small frontal bone ( J:167570 )

decreased fetal size ( J:167570 )

• at E18.5

cellular

abnormal cell physiology ( J:167570 )

• mouse embryonic fibroblasts exhibit impaired response against Wnt stimulation compared with wild-type mice

craniofacial

small frontal bone ( J:167570 )