About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cnot3tm1Pngr
targeted mutation 1, Josef M Penninger
MGI:4881781
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cnot3tm1Pngr/Cnot3tm1Pngr B6.Cg-Cnot3tm1Pngr MGI:4881788
ht2
 		Cnot3tm1Pngr/Cnot3+ B6.Cg-Cnot3tm1Pngr MGI:4881789


Genotype
MGI:4881788
hm1
Allelic
Composition		 Cnot3tm1Pngr/Cnot3tm1Pngr
Genetic
Background		 B6.Cg-Cnot3tm1Pngr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot3tm1Pngr mutation (0 available); any Cnot3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality at implantation, complete penetrance ( J:167954 )
• no newborns recovered
• no placental implantations

embryo
abnormal inner cell mass morphology ( J:167954 )
• outgrowth of inner cell mass begins but severe outgrowth defects occur
• trophoblast develops




Genotype
MGI:4881789
ht2
Allelic
Composition		 Cnot3tm1Pngr/Cnot3+
Genetic
Background		 B6.Cg-Cnot3tm1Pngr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot3tm1Pngr mutation (0 available); any Cnot3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:167954 )
• morphological changes observed 3 weeks after transverse cardiac constriction are reduced to levels observed in controls when treated with histone deacetylase inhibitors
increased heart weight ( J:167954 )
• heart weight/body weight ratio shows a significantly greater increase than in controls 3 weeks after transverse cardiac constriction
cardiac hypertrophy ( J:167954 )
• observed histologically 3 weeks after transverse cardiac constriction
increased heart left ventricle size ( J:167954 )
• increased left ventricular diameter during systole
cardiac fibrosis ( J:167954 )
• severe 3 weeks after transverse cardiac constriction
abnormal cardiovascular system physiology ( J:167954 )
• heart function improves after treatment with histone deacetylase inhibitors
decreased cardiac muscle contractility ( J:167954 )
• defective contractility on electrical stimulation
decreased ventricle muscle contractility ( J:167954 )
• decreased left ventricular fractional shortening
• also observed in explanted heart Langendorff preparations treated with isoproterenol
decreased left ventricle developed pressure ( J:167954 )
• impaired generation of left ventricular pressure in Langendorff preparations treated with isoproterenol

muscle
decreased cardiac muscle contractility ( J:167954 )
• defective contractility on electrical stimulation
decreased ventricle muscle contractility ( J:167954 )
• decreased left ventricular fractional shortening
• also observed in explanted heart Langendorff preparations treated with isoproterenol

growth/size/body
increased heart weight ( J:167954 )
• heart weight/body weight ratio shows a significantly greater increase than in controls 3 weeks after transverse cardiac constriction
cardiac hypertrophy ( J:167954 )
• observed histologically 3 weeks after transverse cardiac constriction




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory