Phenotypes associated with this allele

• Allele Symbol: Ssr3^tm1Ryn
• Allele Name: targeted mutation 1, Ryuichi Nishinakamura
• Allele ID: MGI:4881708
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ssr3^tm1Ryn/Ssr3^tm1Ryn	involves: C57BL/6 * CBA	MGI:4881709

Genotype
MGI:4881709

hm1

• Allelic Composition: Ssr3^tm1Ryn/Ssr3^tm1Ryn
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:167832 )

• all die within a few hours of birth

embryo

abnormal placenta morphology ( J:167832 )

• significant reduction in the size of the blood space at the border of the trophoblast cell layer and maternal decidua at E18.5

abnormal placenta vasculature ( J:167832 )

• At E13.5 in the chorionic plate region there is a reduced number of embryonic blood vessels and little expansion of the network compared to control littermates

• significant reduction in the numbers of embryonic blood vessels in the chorionic plate region at E18.5

abnormal placental labyrinth vasculature morphology ( J:167832 )

• at E13.5, the vascular network is sparser

• extensive reduction vascular networks in the labyrinth layer at E18.5

decreased placental labyrinth size ( J:167832 )

• reduced in size at E18.5

small placenta ( J:167832 )

• at E13.5 and E18.5

decreased placenta weight ( J:167832 )

• at E18.5

abnormal placenta physiology ( J:167832 )

• poor proliferation of embryonic vascular endothelial cells in the chorionic plate at E13.5

increased placenta apoptosis ( J:167832 )

• increase in apoptosis in the labyrinth and junctional zones at E13.5

respiratory system

abnormal pulmonary alveolus morphology ( J:167832 )

• smaller and appear to be collapsed at E18.5

growth/size/body

decreased fetal weight ( J:167832 )

• at E18.5

fetal growth retardation ( J:167832 )

• severely growth delayed at E18.5

• principal organs are all formed but are smaller than in control littermates

cardiovascular system

abnormal placenta vasculature ( J:167832 )

• At E13.5 in the chorionic plate region there is a reduced number of embryonic blood vessels and little expansion of the network compared to control littermates

• significant reduction in the numbers of embryonic blood vessels in the chorionic plate region at E18.5

abnormal placental labyrinth vasculature morphology ( J:167832 )

• at E13.5, the vascular network is sparser

• extensive reduction vascular networks in the labyrinth layer at E18.5

cellular

increased placenta apoptosis ( J:167832 )

• increase in apoptosis in the labyrinth and junctional zones at E13.5