All Phenotypes Tg(Cd4-Zbtb16)1797Aben MGI Mouse

immune system

• CD44^hiCD62L^lo CD4+ T cell subset is increased 5 to 10 times in thymocytes, splenocytes, lung and liver lymphocytes

increased T-helper 2 cell number ( J:139690 )

• IL4 and IFNG producing T cells are increased 4-6 fold following stimulation with anti-CD3 and human IL2 as compared to control

• CD4+ T cells are reduced by greater than 10 fold in the blood and lymph nodes; remaining T cells are CD8+

• normal numbers of CD4+ cells exist in the thymus, spleen, liver and lung

hematopoietic system

• CD44^hiCD62L^lo CD4+ T cell subset is increased 5 to 10 times in thymocytes, splenocytes, lung and liver lymphocytes

increased T-helper 2 cell number ( J:139690 )

• IL4 and IFNG producing T cells are increased 4-6 fold following stimulation with anti-CD3 and human IL2 as compared to control

• CD4+ T cells are reduced by greater than 10 fold in the blood and lymph nodes; remaining T cells are CD8+

• normal numbers of CD4+ cells exist in the thymus, spleen, liver and lung

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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