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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fbxo41tm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:4881288
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fbxo41tm1(KOMP)Vlcg/Fbxo41tm1(KOMP)Vlcg involves: C57BL/6NTac MGI:5776487


Genotype
MGI:5776487
hm1
Allelic
Composition
Fbxo41tm1(KOMP)Vlcg/Fbxo41tm1(KOMP)Vlcg
Genetic
Background
involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo41tm1(KOMP)Vlcg mutation (1 available); any Fbxo41 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive beyond 10 weeks
• most mice die before P14

nervous system
N
• young mice do not exhibit any signs of apoptosis or inflammation in the brain
• delayed neuronal migration in the cerebellum
• thick in young cerebellum at P12
• mitotic PCNA+ cells in the residual external granule cell layer at P16
• severe at P16
• increased number of cells

behavior/neurological
• severe
• dragging of the hind limbs

growth/size/body
• severe at P16
• slight developmental delay at P5

cellular
• delayed neuronal migration in the cerebellum





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory