Phenotypes associated with this allele

• Allele Symbol: Pthlh^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4880897
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pthlh^tm1a(KOMP)Wtsi/Pthlh^tm1a(KOMP)Wtsi	C57BL/6N-Pthlh^tm1a(KOMP)Wtsi/Wtsi	MGI:5631454
ht2	Pthlh^tm1a(KOMP)Wtsi/Pthlh^+	C57BL/6N-Pthlh^tm1a(KOMP)Wtsi/Wtsi	MGI:5706072

Genotype
MGI:5631454

hm1

• Allelic Composition: Pthlh^{tm1a(KOMP)Wtsi}/Pthlh^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Pthlh^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0798_1_C02

Data Sources

IMPC Data for Pthlh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal brain vasculature morphology ( J:239583 )

DMDD

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

abnormal inferior vena cava morphology ( J:239583 )

DMDD

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

neoplasm

embryo tumor ( J:239583 )

DMDD

nervous system

abnormal brain vasculature morphology ( J:239583 )

DMDD

abnormal forebrain morphology ( J:239583 )

DMDD

normal phenotype

no abnormal phenotype detected ( J:239583 )

DMDD

skeleton

abnormal cervical rib ( J:239583 )

DMDD

Genotype
MGI:5706072

ht2

• Allelic Composition: Pthlh^{tm1a(KOMP)Wtsi}/Pthlh⁺
• Genetic Background: C57BL/6N-Pthlh^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0798_1_C02

Data Sources

IMPC Data for Pthlh

craniofacial

abnormal cranium morphology ( J:211773 )

IMPC - WTSI

growth/size/body

abnormal head morphology ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased blood urea nitrogen level ( J:211773 )

♀

IMPC - WTSI

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - WTSI