Phenotypes associated with this allele

• Allele Symbol: Bpifb1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4880889
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bpifb1^tm1a(KOMP)Wtsi/Bpifb1^tm1a(KOMP)Wtsi	C57BL/6N-Bpifb1^tm1a(KOMP)Wtsi	MGI:6098745

Genotype
MGI:6098745

hm1

• Allelic Composition: Bpifb1^{tm1a(KOMP)Wtsi}/Bpifb1^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Bpifb1^{tm1a(KOMP)Wtsi}
• Cell Lines: EPD0704_3_A09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

transmission ratio distortion ( J:245692 )

• Background Sensitivity: depletion of homozygotes in the third generation

• however, this effect is not observed in subsequent generations

respiratory system

abnormal respiratory system physiology ( J:245692 )

• 3-fold increased MUC5B in bronchoalveolar fluid of mice under baseline conditions, which persists after sensitization and challenge

• however, MUC5A production is normal