Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock4tm1(NCOM)Mfgc mutation
(0 available);
any
Dock4 mutation
(108 available)
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mortality/aging
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• no homozygotes are recovered at E7.5
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Allelic
Composition |
Dock4tm1(NCOM)Mfgc/Dock4+
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Genetic
Background |
involves: C57BL/6J * C57BL/6NCrl |
| Cell Lines |
N01793P1_C_109W_G2 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock4tm1(NCOM)Mfgc mutation
(0 available);
any
Dock4 mutation
(108 available)
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Dock4tm1(NCOM)Mfgc/Dock4+ embryos show an increase in the frequency of blood vessels with small lumen width and a decrease in the frequency of large lumen width in the brain
cardiovascular system
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• following implantation of a syngeneic breast cancer cell line (EO771) into the striatum of 9-10 week old heterozygotes, tumors show a reduction in blood vessel lumen width with 21% of vessels having lumens of larger caliber (>35 um) relative to ~38% in control tumors
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• during developmental angiogenesis, E13.5 heterozygotes show only 9% of blood vessels with lumens of relatively large caliber (>20 um) in the brain parenchyma relative to ~31% in wild-type controls
• at E13.5, heterozygotes show a significant reduction in average blood vessel lumen width in the brain (15.1 um vs 18.6 um) relative to wild-type controls
• however, no differences in pericyte coverage of blood vessels are detected in the brain at E13.5
• no differences are detected in the lumen caliber of the aortas at E13.5
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neoplasm
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• following implantation of a syngeneic breast cancer cell line (EO771) into the striatum of 9-10 week old heterozygotes, tumors show a reduction in blood vessel lumen width with 21% of vessels having lumens of larger caliber (>35 um) relative to ~38% in control tumors
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Analysis Tools