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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cngb1tm1.1Glf
targeted mutation 1.1, Gordon L Fain
MGI:4878880
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cngb1tm1.1Glf/Cngb1tm1.1Glf involves: 129/Sv * C57BL/6 MGI:4881533
cx2
 		Cngb1tm1.1Glf/Cngb1tm1.1Glf
Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc 		involves: 129/Sv * 129S1/Sv * C57BL/6 MGI:4881534
cx3
 		Cngb1tm1.1Glf/Cngb1tm1.1Glf
Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc 		involves: 129/Sv * 129S1/Sv * C57BL/6 MGI:4881535


Genotype
MGI:4881533
hm1
Allelic
Composition		 Cngb1tm1.1Glf/Cngb1tm1.1Glf
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cngb1tm1.1Glf mutation (0 available); any Cngb1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:166744 )
N
• no defects in retina morphology are detected
abnormal rod electrophysiology ( J:166744 )
• the limiting time constant of the time the rods remain in saturation is reduced compared to wild-type rods




Genotype
MGI:4881534
cx2
Allelic
Composition		 Cngb1tm1.1Glf/Cngb1tm1.1Glf
Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc
Genetic
Background		 involves: 129/Sv * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cngb1tm1.1Glf mutation (0 available); any Cngb1 mutation (61 available)
Guca1a/Guca1btm1Jnc mutation (0 available); any Guca1b mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal rod electrophysiology ( J:166744 )
• as in mice homozygous for Guca1a/Guca1btm1Jnc alone, flash sensitivity declines more rapidly as a function of background light intensity compared to wild-type mice
• when dark adapted rods are exposed to prolonged steps of light of varying duration the initial rapid decrease in circulating current seen in wild-type rods is absent but a slower current increase is seen and the turning off of light produces a transient overshoot
• the amplitudes of the slow recovery phase and of the overshoot are somewhat larger than in mice homozygous for Guca1a/Guca1btm1Jnc alone




Genotype
MGI:4881535
cx3
Allelic
Composition		 Cngb1tm1.1Glf/Cngb1tm1.1Glf
Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc
Genetic
Background		 involves: 129/Sv * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cngb1tm1.1Glf mutation (0 available); any Cngb1 mutation (61 available)
Guca1a/Guca1btm1Jnc mutation (0 available); any Guca1a mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal rod electrophysiology ( J:166744 )
• as in mice homozygous for Guca1a/Guca1btm1Jnc alone, flash sensitivity declines more rapidly as a function of background light intensity compared to wild-type mice
• when dark adapted rods are exposed to prolonged steps of light of varying duration the initial rapid decrease in circulating current seen in wild-type rods is absent but a slower current increase is seen and the turning off of light produces a transient overshoot
• the amplitudes of the slow recovery phase and of the overshoot are somewhat larger than in mice homozygous for Guca1a/Guca1btm1Jnc alone




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory