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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dmbt1tm2Qaa
targeted mutation 2, Qais Al-Awqati
MGI:4868734
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dmbt1tm2Qaa/Dmbt1tm2Qaa
Tg(ATP6V1B1-cre)45Rnel/0 		involves: C57BL/6 * C57BL/6J * CBA MGI:4868736
cn2
 		Dmbt1tm2Qaa/Dmbt1tm2Qaa
Tg(Hoxb7-cre)5526Cmb/0 		involves: C57BL/6 * FVB/N MGI:4868735


Genotype
MGI:4868736
cn1
Allelic
Composition		 Dmbt1tm2Qaa/Dmbt1tm2Qaa
Tg(ATP6V1B1-cre)45Rnel/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmbt1tm2Qaa mutation (0 available); any Dmbt1 mutation (110 available)
Tg(ATP6V1B1-cre)45Rnel mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
metabolic acidosis ( J:167156 )
• metabolic acidosis

renal/urinary system
abnormal kidney cortex morphology ( J:167156 )
• in the kidney cortex, beta-intercalated cells are replaced with alpha-intercalated cells unlike in wild-type mice

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:167156 )
N
• mice exhibit normal compound action potentials




Genotype
MGI:4868735
cn2
Allelic
Composition		 Dmbt1tm2Qaa/Dmbt1tm2Qaa
Tg(Hoxb7-cre)5526Cmb/0
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmbt1tm2Qaa mutation (0 available); any Dmbt1 mutation (110 available)
Tg(Hoxb7-cre)5526Cmb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
metabolic acidosis ( J:167156 )
• metabolic acidosis

renal/urinary system
abnormal kidney cortex morphology ( J:167156 )
• in the kidney cortex, beta-intercalated cells are replaced with alpha-intercalated cells unlike in wild-type mice

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:167156 )
N
• mice exhibit normal compound action potentials




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory