Phenotypes associated with this allele

• Allele Symbol: Otx2^tm8.2Sia
• Allele Name: targeted mutation 8.2, Shinichi Aizawa
• Allele ID: MGI:4867634
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm8.2Sia/Otx2^tm8.2Sia	involves: C57BL/6 * CBA	MGI:4867635
cx2	Otx1^tm1Sia/Otx1^tm1Sia Otx2^tm8.2Sia/Otx2^tm8.2Sia	involves: C57BL/6 * CBA	MGI:4867636

Genotype
MGI:4867635

hm1

• Allelic Composition: Otx2^tm8.2Sia/Otx2^tm8.2Sia
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain development ( J:166617 )

• at E9.5, the Otx1+ rostral brain is decreased compared to in wild-type mice

• at E9.5, the Gbx2+ anterior hindbrain is expanded compared to in wild-type mice

• at E9.5 and E10.5, the diencephalic and mesenchephalic regions are reduced compared to in wild-type mice

• at E10.5, the Gbx2+ isthmus is anteriorly expanded compared to in wild-type mice

• however, brain morphology is normal at E15.5 and E18.5

abnormal cerebral cortex morphology ( J:166617 )

• mice exhibit mild defects in the medial pallium compared to in wild-type mice

Genotype
MGI:4867636

cx2

• Allelic Composition: Otx1^tm1Sia/Otx1^tm1Sia; Otx2^tm8.2Sia/Otx2^tm8.2Sia
• Genetic Background: involves: C57BL/6 * CBA

nervous system

abnormal midbrain-hindbrain boundary morphology ( J:166617 )

• the isthmus is expanded anteriorly compared to in wild-type mice

• isthmic cells are abnormally organized with overgrowth in the ventricular zone cells that faces the fourth ventricle

absent tectum ( J:166617 )

absent tegmentum ( J:166617 )

absent midbrain ( J:166617 )

• the mesencephalon is absent unlike in wild-type mice

increased pons size ( J:166617 )

• expanded anteriorly

absent diencephalon ( J:166617 )

• the diencephalon is absent unlike in wild-type mice

abnormal cerebral cortex morphology ( J:166617 )

• the medial pallium is residual with caudal deformation compared to in wild-type mice

abnormal embryonic/fetal subventricular zone morphology ( J:166617 )

• ganglionic eminences are hyperplastic compared to in wild-type mice