Phenotypes associated with this allele

• Allele Symbol: Sirt6^tm2.1Cxd
• Allele Name: targeted mutation 2.1, Chu-Xia Deng
• Allele ID: MGI:4867399
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd	involves: 129S6/SvEvTac * NIH Black Swiss	MGI:4867472

Genotype
MGI:4867472

hm1

• Allelic Composition: Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd
• Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:167023 )

• most mice die prior to 1 months of age with remaining mice dying within one year

• however, supplementing drinking water with glucose improves survival

premature aging ( J:167023 )

• mice exhibit kyphosis, reduced bone density, and increased staining for cellular senescence (increased staining for acidic beta-galactosidase) compared with wild-type mice

reproductive system

reduced female fertility ( J:167023 )

♀ • only 6 of 12 female mice produce litters when mated to wild-type males

male infertility ( J:167023 )

♂ • male mice cannot impregnate wild-type females unlike wild-type males

♂ • however, sperm is capable of fertilizing eggs normally in vitro

homeostasis/metabolism

abnormal glucose homeostasis ( J:167023 )

• insulin-stimulated glucose uptake in increased in the quadriceps, white adipose tissue, spleen, liver, thymus, and lung compared to in wild-type mice

decreased circulating glucose level ( J:167023 )

• throughout nursing

• however, supplementing drinking water with glucose improves circulating glucose levels

hypoglycemia ( J:167023 )

• as early as P3

decreased circulating insulin level ( J:167023 )

increased insulin sensitivity ( J:167023 )

skeleton

malocclusion ( J:167023 )

lordokyphosis ( J:167023 )

decreased bone mineral density ( J:167023 )

growth/size/body

malocclusion ( J:167023 )

decreased body size ( J:167023 )

• at P15 and onward

decreased body weight ( J:167023 )

• starting at P3

adipose tissue

decreased subcutaneous adipose tissue amount ( J:167023 )

decreased total body fat amount ( J:167023 )

• as animals live (visceral and subcutaneous)

vision/eye

abnormal eye morphology ( J:167023 )

• with discharge and not fully open eyes

narrow eye opening ( J:167023 )

immune system

abnormal spleen physiology ( J:167023 )

• glucose uptake in the spleen is greater than in wild-type mice

behavior/neurological

abnormal nursing ( J:167023 )

♀ • mice cannot nurse their young unlike wild-type mice

craniofacial

malocclusion ( J:167023 )

cellular

early cellular replicative senescence ( J:167023 )

• mice exhibit increased staining for acidic beta-galactosidase compared with wild-type mice

integument

decreased subcutaneous adipose tissue amount ( J:167023 )