Phenotypes associated with this allele

• Allele Symbol: Khk^tm1.1Dtb
• Allele Name: targeted mutation 1.1, David T Bonthron
• Allele ID: MGI:4867311
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Khk^tm1.1Dtb/Khk^tm1.1Dtb	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:4867312

Genotype
MGI:4867312

hm1

• Allelic Composition: Khk^tm1.1Dtb/Khk^tm1.1Dtb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:166959 )

N • mice exhibit normal development

adipose tissue

abnormal epididymal fat pad morphology ( J:182240 )

♂ • mice fed 30% fructose show higher epididymal fat mass than wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:166959 )

N • mice exhibit normal blood chemistry and tissue metabolite levels

abnormal blood homeostasis ( J:182240 )

♂ • serum fructose levels are increased at baseline

increased circulating insulin level ( J:182240 )

♂ • mice fed 30% fructose show higher serum insulin level than wild-type mice

increased circulating leptin level ( J:182240 )

♂ • mice fed 30% fructose show higher serum leptin level than wild-type mice

increased liver triglyceride level ( J:182240 )

♂ • mice fed 30% fructose show higher intrahepatic triglyceride levels than wild-type mice

abnormal metabolism ( J:182240 )

♂ • mice fed 30% fructose show worse features of metabolic syndrome than wild-type mice, with higher epididymal fat mass, serum insulin, serum leptin, intrahepatic triglycerides and FAS expression, and much more severe hepatic steatosis at 25 weeks of high fructose diet, with no difference in fasting serum glucose

♂ • however, 2-month-old mice show no differences in body weight, liver, and epididymal fat weight, blood pressure, or biochemical analyses at baseline and mice show similar total ingestion of fructose water, chow, and total cumulative energy intake, similar slight increase in urinary fructose, increase in total energy expenditure and in sustained positive energy balance as wild-type mice

liver/biliary system

abnormal liver morphology ( J:182240 )

♂ • mice fed 30% fructose show higher intrahepatic fructose levels than wild-type mice

increased liver triglyceride level ( J:182240 )

♂ • mice fed 30% fructose show higher intrahepatic triglyceride levels than wild-type mice

increased susceptibility to hepatic steatosis ( J:182240 )

♂ • mice fed 30% fructose show much more severe hepatic steatosis at 25 weeks of the high fructose diet than wild-type mice

reproductive system

reproductive system phenotype ( J:166959 )

N • mice exhibit normal fertility