Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3btm1.1Ypc mutation
(0 available);
any
Gsk3b mutation
(111 available)
Osr2tm2(cre)Jian mutation
(1 available);
any
Osr2 mutation
(17 available)
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mortality/aging
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N |
• unlike germline null mice, mice survive postnatally
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craniofacial
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N |
• unlike in germline null mice, palate formation is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3btm1.1Ypc mutation
(0 available);
any
Gsk3b mutation
(111 available)
Tg(Pitx2-cre)1Ych mutation
(0 available)
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craniofacial
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• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation
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• 11 of 14 mice show complete cleft of the secondary palate
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• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue
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digestive/alimentary system
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• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation
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• 11 of 14 mice show complete cleft of the secondary palate
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• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue
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growth/size/body
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• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation
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• 11 of 14 mice show complete cleft of the secondary palate
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• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue
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Analysis Tools