All Phenotypes Lin28a<tm1Egm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lin28a^tm1Egm
targeted mutation 1, Eric G Moss
MGI:4849371

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lin28a^tm1Egm/Lin28a^tm1Egm	involves: 129S/SvEv	MGI:4849445
hm2	Lin28a^tm1Egm/Lin28a^tm1Egm	involves: 129S/SvEv * C57BL/6NTac	MGI:5500063

Allelic Composition	Lin28a^tm1Egm/Lin28a^tm1Egm
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1Egm mutation (0 available); any Lin28a mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:166568 )

growth/size/body

decreased birth weight ( J:166568 )

Allelic Composition	Lin28a^tm1Egm/Lin28a^tm1Egm
Genetic Background	involves: 129S/SvEv * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1Egm mutation (0 available); any Lin28a mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased germ cell number ( J:196313 )

• in neonates

decreased oocyte number ( J:196313 )

• following hormone-induced superovulation

oligozoospermia ( J:196313 )

decreased primordial germ cell number ( J:196313 )

• in genital ridges at E13.5

decreased primordial ovarian follicle number ( J:196313 )

• however, the number of maturing follicles and corpora lutea are normal

decreased ovary weight ( J:196313 )

reduced female fertility ( J:196313 )

decreased litter size ( J:196313 )

• from female and male mice

• however, older male mice produce normal-sized litters

reduced male fertility ( J:196313 )

growth/size/body

decreased body size ( J:196313 )

decreased body weight ( J:196313 )

homeostasis/metabolism

decreased circulating testosterone level ( J:196313 )

• in older male mice

• however, luteinizing hormone levels are normal

decreased circulating follicle stimulating hormone level ( J:196313 )

• in male mice

behavior/neurological

reduced male mating frequency ( J:196313 )

• in older male mice

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:196313 )

• however, the number of maturing follicles and corpora lutea are normal

decreased ovary weight ( J:196313 )

cellular

decreased germ cell number ( J:196313 )

• in neonates

decreased oocyte number ( J:196313 )

• following hormone-induced superovulation

oligozoospermia ( J:196313 )

decreased primordial germ cell number ( J:196313 )

• in genital ridges at E13.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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