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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myo3atm1.1Mckg
targeted mutation 1.1, Mary-Claire King
MGI:4849286
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myo3atm1.1Mckg/Myo3atm1.1Mckg C57BL/6-Myo3atm1.1Mckg MGI:4849847


Genotype
MGI:4849847
hm1
Allelic
Composition		 Myo3atm1.1Mckg/Myo3atm1.1Mckg
Genetic
Background		 C57BL/6-Myo3atm1.1Mckg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo3atm1.1Mckg mutation (1 available); any Myo3a mutation (109 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:166812 )
N
• mice exhibit normal vestibular function
decreased cochlear outer hair cell number ( J:166812 )
• severe at 10 months
• degeneration in the mid-cochlear turn is more severe
impaired hearing ( J:166812 )
• at 2.5 months, mice exhibit significant hearing loss which progreses with age compared with wild-type mice

nervous system
decreased cochlear outer hair cell number ( J:166812 )
• severe at 10 months
• degeneration in the mid-cochlear turn is more severe

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autosomal recessive nonsyndromic deafness 30 DOID:0110489 OMIM:607101
 J:166812




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory