Phenotypes associated with this allele

• Allele Symbol: Fth1^tm1Lck
• Allele Name: targeted mutation 1, Lukas C Kuhn
• Allele ID: MGI:4847957
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fth1^tm1Lck/Fth1^tm1Lck	involves: 129/Sv * C57BL/6 * FVB/N	MGI:4848039

Genotype
MGI:4848039

cn1

• Allelic Composition: Fth1^tm1Lck/Fth1^tm1Lck
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:166515 )

• following in vitro cre-mediated recombination, mouse embryonic fibroblasts exposed to iron exhibit loss of membrane integrity, increased cytoplasmic iron levels, reactive oxygen species formation, and mitochondrial depolarization compared with iron exposed un-recombined cells

increased sensitivity to induced cell death ( J:166515 )

• following in vitro cre-mediated recombination, mouse embryonic fibroblasts are 30-fold more sensitive to iron compared un-recombined cells

abnormal mitochondrial physiology ( J:166515 )

• following in vitro cre-mediated recombination, mouse embryonic fibroblasts exposed to iron exhibit mitochondrial depolarization unlike iron exposed un-recombined cells