Phenotypes associated with this allele

• Allele Symbol: Ctsg^{tm3.1(PML/RARA)Ley}
• Allele Name: targeted mutation 3.1, Timothy J Ley
• Allele ID: MGI:4847629
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ctsg^tm3.1(PML/RARA)Ley/Ctsg^+	involves: 129 * C57BL/6	MGI:4847633

Genotype
MGI:4847633

ht1

• Allelic Composition: Ctsg^{tm3.1(PML/RARA)Ley}/Ctsg⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:166479 )

• median survival is 269 to 290 days compared with 473 days for Ctsg^{tm2.1(PML/RARA)Ley} heterozygotes

hematopoietic system

abnormal bone marrow cell morphology/development ( J:166479 )

• bone marrow cells exhibit increased replating efficiency as determined by increased colony formation compared with wild-type bone marrow

abnormal common myeloid progenitor cell morphology ( J:166479 )

• mice exhibit an increase in Gr-1+ and Gr-1+/CD117+ cells in the spleen compared with wild-type mice

abnormal spleen morphology ( J:166479 )

• mice exhibit an increase in Gr-1+ and Gr-1+/CD117+ cells in the spleen compared with wild-type mice

enlarged spleen ( J:166479 )

increased spleen weight ( J:166479 )

neoplasm

increased acute promyelocytic leukemia incidence ( J:166479 )

• most mice develop acute myeloid leukemia with promyelocytic features, including periperal leukocytosis and infiltration of the spleen and bone marrow with Gr-1+ CD117+ tumor cells unlike wild-type mice

• median tumor free survival is decreased compared to in Ctsg^{tm2.1(PML/RARA)Ley} heterozygotes

immune system

abnormal spleen morphology ( J:166479 )

• mice exhibit an increase in Gr-1+ and Gr-1+/CD117+ cells in the spleen compared with wild-type mice

enlarged spleen ( J:166479 )

increased spleen weight ( J:166479 )

growth/size/body

enlarged spleen ( J:166479 )

increased spleen weight ( J:166479 )