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Allele Symbol Allele Name Allele ID |
Tg(CLEC4C-HBEGF)956Cln transgene insertion 956, Marco Colonna MGI:4847575 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• diptheria toxin administration induces selective depletion of plasmacytoid dendritic cells (pDC), but does not reduce numbers of classical DC
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• diptheria toxin administration induces selective depletion of plasmacytoid dendritic cells (pDC), but does not reduce numbers of classical DC
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• diptheria toxin (DT) administration induced depletion of plasmacytoid dendritic cells (pDC)
• depletion efficiency in blood, spleen, liver and lymph nodes is approximately 90% 24-48 hrs after DT treatment
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• decreased frequencies and numbers of antigen-specific CD8+ T cells in DT-treated mice infected with recombinant VSV expressing ovalbumin (VSV-OVA)
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• spleens from VSV-OVA infected DT-treated mice are smaller and have fewer cells than controls
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• spleens from VSV-OVA infected DT-treated mice are smaller and have fewer cells than controls
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• 2.5 fold increase in number of IFNg-producing NK cells in DT-treated (pDC-depleted) mice as compared to untreated control
• increase in frequency of NK1.1+ and Ly49H+ NK cells in DT-treated (pDC-depleted) mice during later phase of murine cytomegalovirus (MCMV) infection as compared to untreated control
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• Ly49H+ NK cells from DT-treated (pDC-depleted) mice are less efficient at killing target cells
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• less specific lysis is observed in antigen-specific CD8+ T cells found in VSV-OVA infected DT-treated mice
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• increased frequencies of IFNg-producing NKT cells found in spleens and livers of DT-treated (pDC-depleted) mice
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• reduction in serum CCL4 observed in VSV-OVA infected DT-treated mice 24 hours post infection (p.i.)
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• DT-treated (pDC-depleted) mice exhibit decreased serum IFNa secretion 36 hours post MCMV infection although no differences are observed at 48 hours p.i.
• DT-treated (pDC-depleted) mice exhibit decreased serum IFNa secretion 6 hours post infection with recombinant VSV expressing ovalbumin (VSV-OVA) but not at 12 or 24 hours p.i.
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• DT-treated (pDC-depleted) mice exhibit a 3-4x increase in serum IFNg secretion as compared to untreated controls 48 hours after MCMV at 104 pfu, but not at 105 pfu
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• increase in IL12 producing CD11chi cells in DT-treated mice as compared to control
• increase in serum IL12 in DT-treated mice
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• intraperitoneal infection with murine cytomegalovirus (MCMV) in DT-treated (pDC-depleted) mice results in significantly higher viral titers in spleen and liver 3 days post infection (3 p.i.) as compared to untreated controls
• salivary glands from MCMV infected DT-treated mice at 8 p.i. have elevated viral loads at 104 pfu, but not at 105 pfu as compared to untreated controls
• infection with recombinant VSV results in higher viral titers in spleen at 6 hours p.i. as compared to untreated controls, but VSV is undetectable in periphery after 24 hours
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• diptheria toxin (DT) administration induced depletion of plasmacytoid dendritic cells (pDC)
• depletion efficiency in blood, spleen, liver and lymph nodes is approximately 90% 24-48 hrs after DT treatment
|
|
• decreased frequencies and numbers of antigen-specific CD8+ T cells in DT-treated mice infected with recombinant VSV expressing ovalbumin (VSV-OVA)
|
|
• spleens from VSV-OVA infected DT-treated mice are smaller and have fewer cells than controls
|
|
• spleens from VSV-OVA infected DT-treated mice are smaller and have fewer cells than controls
|
|
• 2.5 fold increase in number of IFNg-producing NK cells in DT-treated (pDC-depleted) mice as compared to untreated control
• increase in frequency of NK1.1+ and Ly49H+ NK cells in DT-treated (pDC-depleted) mice during later phase of murine cytomegalovirus (MCMV) infection as compared to untreated control
|
|
• Ly49H+ NK cells from DT-treated (pDC-depleted) mice are less efficient at killing target cells
|
|
• less specific lysis is observed in antigen-specific CD8+ T cells found in VSV-OVA infected DT-treated mice
|
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• increased frequencies of IFNg-producing NKT cells found in spleens and livers of DT-treated (pDC-depleted) mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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