All Phenotypes Tg(Dbh-cre)KH212Gsat MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Dbh-cre)KH212Gsat
transgene insertion KH212, GENSAT Project at Rockefeller University
MGI:4846983

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Clstn3^{tm1c(EUCOMM)Hmgu}/Clstn3^{tm1c(EUCOMM)Hmgu} Tg(Dbh-cre)KH212Gsat/0	involves: C57BL/6 * C57BL/6N * FVB/NTac * SJL	MGI:6454087
cn2	Egr3^tm1Jmi/Egr3^tm1Jmi Gt(ROSA)26Sor^{tm1(CAG-taulacZ)Bene}/Gt(ROSA)26Sor⁺ Tg(Dbh-cre)KH212Gsat/0	involves: C57BL/6 * FVB/NTac	MGI:5489938

Allelic Composition	Clstn3^{tm1c(EUCOMM)Hmgu}/Clstn3^{tm1c(EUCOMM)Hmgu} Tg(Dbh-cre)KH212Gsat/0
Genetic Background	involves: C57BL/6 * C57BL/6N * FVB/NTac * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clstn3^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Clstn3 mutation (65 available)
Tg(Dbh-cre)KH212Gsat mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:293885 )

N	• normal body weight

limbs/digits/tail

limbs/digits/tail phenotype ( J:293885 )

N	• normal bone morphology

Allelic Composition	Egr3^tm1Jmi/Egr3^tm1Jmi Gt(ROSA)26Sor^{tm1(CAG-taulacZ)Bene}/Gt(ROSA)26Sor⁺ Tg(Dbh-cre)KH212Gsat/0
Genetic Background	involves: C57BL/6 * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3^tm1Jmi mutation (2 available); any Egr3 mutation (15 available)
Gt(ROSA)26Sor^{tm1(CAG-taulacZ)Bene} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Dbh-cre)KH212Gsat mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:196371 )

N	• no significant differences are detected in sympathetic axon guidance; axon guidance to the submandibular gland is similar in mutants and controls

abnormal sympathetic neuron morphology ( J:196371 )

• (lacZ-labeled) mutant neurons have fewer primary dendrites compared to controls in the superior cervical ganglion (SCG) and stellate ganglion; labeled neurons have decreased total dendrite length and decrease in maximum extent of the dendritic arbor in the SCG

• neurons are significantly atrophic compared with control (decreased mean soma area)

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