Phenotypes associated with this allele

• Allele Symbol: Tg(Dbh-cre)KH212Gsat
• Allele Name: transgene insertion KH212, GENSAT Project at Rockefeller University
• Allele ID: MGI:4846983
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Clstn3^tm1c(EUCOMM)Hmgu/Clstn3^tm1c(EUCOMM)Hmgu Tg(Dbh-cre)KH212Gsat/0	involves: C57BL/6 * C57BL/6N * FVB/NTac * SJL	MGI:6454087
cn2	Egr3^tm1Jmi/Egr3^tm1Jmi Gt(ROSA)26Sor^tm1(CAG-taulacZ)Bene/Gt(ROSA)26Sor^+ Tg(Dbh-cre)KH212Gsat/0	involves: C57BL/6 * FVB/NTac	MGI:5489938

Genotype
MGI:6454087

cn1

• Allelic Composition: Clstn3^{tm1c(EUCOMM)Hmgu}/Clstn3^{tm1c(EUCOMM)Hmgu}; Tg(Dbh-cre)KH212Gsat/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/NTac * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:293885 )

N • normal body weight

limbs/digits/tail

limbs/digits/tail phenotype ( J:293885 )

N • normal bone morphology

Genotype
MGI:5489938

cn2

• Allelic Composition: Egr3^tm1Jmi/Egr3^tm1Jmi; Gt(ROSA)26Sor^{tm1(CAG-taulacZ)Bene}/Gt(ROSA)26Sor⁺; Tg(Dbh-cre)KH212Gsat/0
• Genetic Background: involves: C57BL/6 * FVB/NTac

nervous system

nervous system phenotype ( J:196371 )

N • no significant differences are detected in sympathetic axon guidance; axon guidance to the submandibular gland is similar in mutants and controls

abnormal sympathetic neuron morphology ( J:196371 )

• (lacZ-labeled) mutant neurons have fewer primary dendrites compared to controls in the superior cervical ganglion (SCG) and stellate ganglion; labeled neurons have decreased total dendrite length and decrease in maximum extent of the dendritic arbor in the SCG

• neurons are significantly atrophic compared with control (decreased mean soma area)