Phenotypes associated with this allele

• Allele Symbol: Hand1^{tm2.1(Hand1)Abfi}
• Allele Name: targeted mutation 2.1, Anthony B Firulli
• Allele ID: MGI:4843975
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hand1^tm2.1(Hand1)Abfi/Hand1^tm2.1(Hand1)Abfi	Not Specified	MGI:4844009
cx2	Hand1^tm2.1(Hand1)Abfi/Hand1^tm2.1(Hand1)Abfi Hand2^tm1Dsr/Hand2^tm1Dsr	involves: 129S7/SvEvBrd	MGI:4844011

Genotype
MGI:4844009

hm1

• Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:164028 )

• majority of embryos are viable to E10.5, with 8% viable to E12.5

cardiovascular system

abnormal cardiovascular system morphology ( J:164028 )

• mice exhibit similar phenotypes to Hand1^{tm1(Hand1)Abfi} but at a less severe penetrance

abnormal cardiac outflow tract development ( J:164028 )

• reduced outflow tract cushions at E12.5

abnormal interventricular septum morphology ( J:164028 )

• septal cardiomyocytes are disorganized in the forming interventricular septum at E12.5

thin ventricular wall ( J:164028 )

• decrease in ventricular wall thickness at E12

hemopericardium ( J:164028 )

• pericardial hemorrhaging at E12.5

craniofacial

abnormal craniofacial morphology ( J:164028 )

• craniofacial defects at E12.5

embryo

abnormal embryo development ( J:164028 )

• mice exhibit similar phenotypes to Hand1^{tm1(Hand1)Abfi} but at a less severe penetrance

abnormal embryo turning ( J:164028 )

• embryo turning is impaired

abnormal rostral-caudal axis patterning ( J:164028 )

• severe caudal defects at E12.5

decreased embryo size ( J:164028 )

• embryos surviving to E12.5 are slightly smaller than wild-type

abnormal limb bud morphology ( J:164028 )

• hypoplastic limb buds at E12.5

growth/size/body

decreased embryo size ( J:164028 )

• embryos surviving to E12.5 are slightly smaller than wild-type

homeostasis/metabolism

hemopericardium ( J:164028 )

• pericardial hemorrhaging at E12.5

cellular

decreased cell proliferation ( J:164028 )

• decrease in the rate of global cell proliferation at E9.5

limbs/digits/tail

abnormal limb bud morphology ( J:164028 )

• hypoplastic limb buds at E12.5

Genotype
MGI:4844011

cx2

• Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi}; Hand2^tm1Dsr/Hand2^tm1Dsr
• Genetic Background: involves: 129S7/SvEvBrd

cardiovascular system

abnormal cardiovascular system morphology ( J:164028 )

• cardiac morphogenesis is comparable to both single mutants

thin ventricular wall ( J:164028 )

• myocardium shows a thin ventricular wall

embryo

abnormal rostral-caudal axis patterning ( J:164028 )

• exhibit poor caudal development compared to either single mutant

decreased embryo size ( J:164028 )

growth/size/body

decreased embryo size ( J:164028 )