Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation
(1 available);
any
Atp11c mutation
(16 available)
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immune system
 N |
• mice exhibit normal fetal B cell lymphopoiesis
(J:171925)
• mice exhibit a normal response to NP-Ficoll and recombinant Semliki Forest virus (SFV) encoded antigen
(J:185495)
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hematopoietic system
immune system
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• the percentage of CD19+ B cells is reduced compared to in wild-type mice
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hematopoietic system
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• the percentage of CD19+ B cells is reduced compared to in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation
(1 available);
any
Atp11c mutation
(16 available)
Tg(IghmHyHEL10,IgkHyHEL10)4Ccg mutation
(0 available)
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immune system
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• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes
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hematopoietic system
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• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation
(1 available);
any
Atp11c mutation
(16 available)
Tg(BCL2)22Wehi mutation
(2 available)
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immune system
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• compared to in Tg(BCL2)22Wehi mice or Atp11cm1Btlr hemizygotes
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• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes
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• as in Atp11cm1Btlr hemizygotes in the bone marrow
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• follicular B cell numbers are partially rescued compared to in Atp11cm1Btlr hemizygotes
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hematopoietic system
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• compared to in Tg(BCL2)22Wehi mice or Atp11cm1Btlr hemizygotes
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• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes
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• as in Atp11cm1Btlr hemizygotes in the bone marrow
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• follicular B cell numbers are partially rescued compared to in Atp11cm1Btlr hemizygotes
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Allelic
Composition |
Atp11cm1Btlr/Y
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Genetic
Background |
involves: C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation
(1 available);
any
Atp11c mutation
(16 available)
|
|
|
immune system
|
N |
• mice exhibit normal allelic exclusion at the immunoglobulin heavy-chain locus
(J:171925)
• mice exhibit normal fetal B cell lymphopoiesis
(J:171925)
• mice exhibit a normal response to NP-Ficoll and recombinant Semliki Forest virus (SFV) encoded antigen
(J:185495)
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• mice exhibit cell-intrinsic failure of adult B lymphopoiesis unlike in wild-type mice
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• the percentage of CD19+ B cells in the blood is reduced compared to in wild-type mice
(J:171925)
• however, mice exhibit normal numbers of marginal zone B cells and Thy-1.2+ cells
(J:171925)
• B cell deficiency
(J:185495)
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• mice exhibit fewer pre-pro-B cells to pro-B cells compared with wild-type mice
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• 3-fold in the peritoneal cavity
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• 10-fold in the peritoneal cavity
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• 50% less high-affinity IgG1 antibodies in response to alum-precipitated NP-CGG
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• 50% less NP-specific IgM antibodies in response to NP-ficoll
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homeostasis/metabolism
hematopoietic system
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• mice exhibit cell-intrinsic failure of adult B lymphopoiesis unlike in wild-type mice
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• the percentage of CD19+ B cells in the blood is reduced compared to in wild-type mice
(J:171925)
• however, mice exhibit normal numbers of marginal zone B cells and Thy-1.2+ cells
(J:171925)
• B cell deficiency
(J:185495)
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• mice exhibit fewer pre-pro-B cells to pro-B cells compared with wild-type mice
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• 3-fold in the peritoneal cavity
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• 10-fold in the peritoneal cavity
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• 50% less high-affinity IgG1 antibodies in response to alum-precipitated NP-CGG
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• 50% less NP-specific IgM antibodies in response to NP-ficoll
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Analysis Tools