Phenotypes associated with this allele

• Allele Symbol: Lepr^tm4Mgmj
• Allele Name: targeted mutation 4, Martin G Myers, Jr
• Allele ID: MGI:4843181
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lepr^tm4Mgmj/Lepr^tm4Mgmj	B6.Cg-Lepr^tm4Mgmj	MGI:4843198

Genotype
MGI:4843198

hm1

• Allelic Composition: Lepr^tm4Mgmj/Lepr^tm4Mgmj
• Genetic Background: B6.Cg-Lepr^tm4Mgmj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal female reproductive system morphology ( J:164339 )

♀ • female mice exhibit atrophic reproductive organs unlike in wild-type mice

absent estrus ( J:164339 )

♀

absent estrous cycle ( J:164339 )

♀

female infertility ( J:164339 )

♀

homeostasis/metabolism

increased circulating glucose level ( J:164339 )

• as early as 6 weeks of age

increased circulating insulin level ( J:164339 )

• in female mice

• in male mice but not as much as in Lepr^db male mice

decreased body temperature ( J:164339 )

• in male mice

impaired glucose tolerance ( J:164339 )

• in male mice

• in female mice but not as much as in Lepr^db male mice

insulin resistance ( J:164339 )

growth/size/body

decreased lean body mass ( J:164339 )

increased body weight ( J:164339 )

decreased body length ( J:164339 )

• in male mice

immune system

decreased T cell proliferation ( J:164339 )

decreased CD4-positive, alpha-beta T cell number ( J:164339 )

decreased splenocyte number ( J:164339 )

adipose tissue

increased percent body fat/body weight ( J:164339 )

behavior/neurological

abnormal eating behavior ( J:164339 )

skeleton

short femur ( J:164339 )

• in male mice

hematopoietic system

decreased T cell proliferation ( J:164339 )

decreased CD4-positive, alpha-beta T cell number ( J:164339 )

decreased splenocyte number ( J:164339 )

limbs/digits/tail

short femur ( J:164339 )

• in male mice

cellular

decreased T cell proliferation ( J:164339 )