All Phenotypes Pkd2<tm1.1Tjwt> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pkd2^tm1.1Tjwt
targeted mutation 1.1, Terry J Watnick
MGI:4843126

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pkd2^tm1.1Tjwt/Pkd2^tm1.1Tjwt	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * SJL	MGI:4843162
cn2	Pkd2^tm1.1Tjwt/Pkd2^tm1.2Tjwt Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4843164
cn3	Pkd2^tm1.1Tjwt/Pkd2^tm1.1Tjwt Tg(Tek-cre)1Ywa/0	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * SJL	MGI:4843169

Allelic Composition	Pkd2^tm1.1Tjwt/Pkd2^tm1.1Tjwt
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2^tm1.1Tjwt mutation (1 available); any Pkd2 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:165114 )

• mice are phenotypically normal

Allelic Composition	Pkd2^tm1.1Tjwt/Pkd2^tm1.2Tjwt Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (21 available)
Pkd2^tm1.1Tjwt mutation (1 available); any Pkd2 mutation (85 available)
Pkd2^tm1.2Tjwt mutation (0 available); any Pkd2 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:165114 )

endocrine/exocrine glands

pancreas cyst ( J:165114 )

cardiovascular system

dextrocardia ( J:165114 )

homeostasis/metabolism

edema ( J:165114 )

• in neonates

growth/size/body

pancreas cyst ( J:165114 )

kidney cyst ( J:165114 )

situs inversus ( J:165114 )

renal/urinary system

kidney cyst ( J:165114 )

Allelic Composition	Pkd2^tm1.1Tjwt/Pkd2^tm1.1Tjwt Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2^tm1.1Tjwt mutation (1 available); any Pkd2 mutation (85 available)
Tg(Tek-cre)1Ywa mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:165114 )

• fewer than expected mice are recovered in the perinatal period

prenatal lethality, incomplete penetrance ( J:165114 )

• fewer than expected mice are recovered between E8.5 and E15.5

embryo

abnormal placenta vasculature ( J:165114 )

• mice exhibit dilation of maternal vasculature in the placenta unlike in wild-type mice

• fewer fetal vessels and investing pericytes are present in the placenta compared to in wild-type mice

• fewer branched placental vessels are observed compared to in wild-type mice

• however, placental layer size is normal

cardiovascular system

abnormal placenta vasculature ( J:165114 )

• mice exhibit dilation of maternal vasculature in the placenta unlike in wild-type mice

• fewer fetal vessels and investing pericytes are present in the placenta compared to in wild-type mice

• fewer branched placental vessels are observed compared to in wild-type mice

• however, placental layer size is normal

hemorrhage ( J:165114 )

• in a small fraction of mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:165114 )

N	• unlike in null mice, no edema is observed

polyhydramnios ( J:165114 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24