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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Katnal2tm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4842422
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Katnal2tm1a(EUCOMM)Wtsi/Katnal2tm1a(EUCOMM)Wtsi C57BL/6N-Katnal2tm1a(EUCOMM)Wtsi MGI:6274235
ht2
 		Katnal2m1Anu/Katnal2tm1a(EUCOMM)Wtsi involves: C57BL/6J * C57BL/6N MGI:6274238


Genotype
MGI:6274235
hm1
Allelic
Composition		 Katnal2tm1a(EUCOMM)Wtsi/Katnal2tm1a(EUCOMM)Wtsi
Genetic
Background		 C57BL/6N-Katnal2tm1a(EUCOMM)Wtsi
Cell Lines EPD0656_4_A03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Katnal2tm1a(EUCOMM)Wtsi mutation (2 available); any Katnal2 mutation (201 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Spermatogenic defects in Katnal2tm1a(EUCOMM)Wtsi/Katnal2tm1a(EUCOMM)Wtsi mice

reproductive system
multinucleated giant male germ cells ( J:250115 )
• multinucleated symplasts are frequently observed in the seminiferous epithelium
abnormal seminiferous tubule epithelium morphology ( J:250115 )
• multinucleated symplasts are frequently observed in the seminiferous epithelium
abnormal spermatid morphology ( J:250115 )
• elongating spermatids frequently exhibit abnormal nuclear morphology
abnormal spermiation ( J:250115 )
• total epididymal sperm content is reduced by 96.8% relative to wild-type controls; however, testis weight and daily sperm output in the testes are normal, indicating a massive failure of spermiation
• retained elongated spermatids are often observed in stage IX seminiferous tubules, unlike in wild-type controls
male infertility ( J:250115 )
• males are sterile and exhibit an apparently identical male fertility phenotype to that observed in Katnal2m1Anu homozygotes

cellular
abnormal spermatid morphology ( J:250115 )
• elongating spermatids frequently exhibit abnormal nuclear morphology
multinucleated giant male germ cells ( J:250115 )
• multinucleated symplasts are frequently observed in the seminiferous epithelium

endocrine/exocrine glands
abnormal seminiferous tubule epithelium morphology ( J:250115 )
• multinucleated symplasts are frequently observed in the seminiferous epithelium




Genotype
MGI:6274238
ht2
Allelic
Composition		 Katnal2m1Anu/Katnal2tm1a(EUCOMM)Wtsi
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Cell Lines EPD0656_4_A03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Katnal2m1Anu mutation (1 available); any Katnal2 mutation (201 available)
Katnal2tm1a(EUCOMM)Wtsi mutation (2 available); any Katnal2 mutation (201 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Spermiation and spermatid defects in Katnal2m1Anu/Katnal2tm1a(EUCOMM)Wtsi mice

reproductive system
abnormal spermatid morphology ( J:250115 )
• elongating spermatids frequently exhibit abnormal nuclear (club shaped) morphology
multinucleated giant male germ cells ( J:250115 )
• multinucleated symplasts are frequently observed in the seminiferous epithelium
abnormal seminiferous tubule epithelium morphology ( J:250115 )
• multinucleated symplasts are frequently observed in the seminiferous epithelium
abnormal spermiation ( J:250115 )
• total epididymal sperm content is reduced by 94.5% relative to wild-type controls; however, testis weight and daily sperm output in the testes are normal, indicating a massive failure of spermiation
• retained elongated spermatids are often observed in stage IX seminiferous tubules, unlike in wild-type controls
male infertility ( J:250115 )
• males are sterile and exhibit an apparently identical male fertility phenotype to that observed in Katnal2m1Anu homozygotes

cellular
abnormal spermatid morphology ( J:250115 )
• elongating spermatids frequently exhibit abnormal nuclear (club shaped) morphology
multinucleated giant male germ cells ( J:250115 )
• multinucleated symplasts are frequently observed in the seminiferous epithelium

endocrine/exocrine glands
abnormal seminiferous tubule epithelium morphology ( J:250115 )
• multinucleated symplasts are frequently observed in the seminiferous epithelium




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
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