Phenotypes associated with this allele

• Allele Symbol: Syde1^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4841821
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syde1^tm1a(EUCOMM)Hmgu/Syde1^tm1a(EUCOMM)Hmgu	involves: C57BL/6N	MGI:5527168

Genotype
MGI:5527168

hm1

• Allelic Composition: Syde1^{tm1a(EUCOMM)Hmgu}/Syde1^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N
• Cell Lines: HEPD0665_7_C10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:201692 )

N • mice exhibit normal cerebellum and hippocampus gross morphology and paired-pulse ratio

abnormal synaptic vesicle number ( J:201692 )

• reduced docked vesicles in CA1 synapses

abnormal miniature excitatory postsynaptic currents ( J:201692 )

• reduced frequency

• however, miniature excitatory postsynaptic current amplitudes are normal

cellular

abnormal synaptic vesicle number ( J:201692 )

• reduced docked vesicles in CA1 synapses