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Allele Symbol Allele Name Allele ID |
Syap1tm1a(EUCOMM)Hmgu targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH MGI:4841544 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• adult mice are viable, fertile and overtly normal with no gross structural changes in brain morphology
• in culture, embryonic primary motoneurons isolated from E13.5 lumbar spinal cords show normal axon growth (length) and survival rate with no significant alterations in total Akt phosphorylation relative to wild-type motoneurons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• adult mice are viable, fertile and overtly normal with no gross structural changes in brain morphology
• in culture, embryonic primary motoneurons show normal axon growth (length) and survival rate with no significant alterations in total Akt phosphorylation relative to wild-type motoneurons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• normal voluntary running distance in a wheel
• normal preference for novel object in novel object recognition test
• normal fear conditioning
• normal preferences in dark-light transition test but with reduced overall locomotor activity
• normal preference for closed arms in elevated plus maze test
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• very short latency to fall in accelerated and rocking rotation rotarod tests
• normal latency to fall with steady rotation in rotarod test
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• slightly but significantly decreased grip strength in hind limbs
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• reduction in total travel distance (mostly in periphery) within first 10 min. in open field test
• mostly stationary, showing orientation-like movement, in first 5 min. in open field test
• normal activity after 15-30 min. in open field test
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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