All Phenotypes Sh2d1b2<tm1.1Cpt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sh2d1b2^tm1.1Cpt
targeted mutation 1.1, Cox Terhorst
MGI:4840393

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh2d1b2^tm1.1Cpt/Sh2d1b2^tm1.1Cpt	involves: BALB/cJ * C57BL/6	MGI:4840404

Allelic Composition	Sh2d1b2^tm1.1Cpt/Sh2d1b2^tm1.1Cpt
Genetic Background	involves: BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1b2^tm1.1Cpt mutation (0 available); any Sh2d1b2 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:166054 )

• NK cells are defective in anti-CD244 dependent killing of 51Cr-labeled P815 cells compared with wild-type mice

• however, cytotolysis of P815 CD48+, YB2/0, YAC-1, and CHO cells is normal

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:166054 )

• NK cells are defective in anti-CD244 dependent killing of 51Cr-labeled P815 cells compared with wild-type mice

• however, cytotolysis of P815 CD48+, YB2/0, YAC-1, and CHO cells is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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